Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.

Sourced imagery — amyloid-cascade academic infographics

Compiled 2026-10-10. Everything below is real, openly licensed scientific imagery/data. No fabricated content.

Photomicrographs / published figures (kept)

File	What it shows	Source	DOI / PMCID	License	Required attribution line
`abeta-tau-ad.tif`	Photomicrograph: Aβ plaques (brown) and neurofibrillary (tau) tangles (black) in AD brain; hyperphosphorylated tau in neuronal cell bodies, neuropil threads, and dystrophic neurites within plaques	Wikimedia Commons, uploaded by user "Tulemo" (own work)	— (no paper)	CC0 (public-domain dedication)	Not legally required; credit as "Image: Tulemo, Wikimedia Commons (CC0)"
`tau-tangles-hippocampus.jpg`	Immunohistochemistry for tau protein: neurofibrillary tangles in hippocampus of an elderly person with Alzheimer-related pathology	Wikimedia Commons, user "Patho" (own work)	— (no paper)	CC BY-SA 3.0 ⚠️ share-alike	"© Patho, CC BY-SA 3.0, via Wikimedia Commons" — note: SA clause means adapted works must carry the same license
`neuropath-features-ad.png`	Published review figure: diagram of neuropathological features of Alzheimer's disease (plaques, tangles, gliosis, vascular changes)	Vidovic N, Spittau B. Int J Mol Sci. 2024;25(6):3090	doi:10.3390/ijms25063090	CC BY 3.0	"Vidovic N, Spittau B (2024), CC BY 3.0, via Wikimedia Commons"
`kollmer2019-fig1.png`	Fig 1: Negative-stain TEM (a), TEM (b) and SEM (c) of brain-derived (ex vivo) vs in vitro Aβ amyloid fibrils. Scale bars: 200 nm	Kollmer M, Close W, Funk L, et al. "Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue." Nat Commun. 2019;10:4760	doi:10.1038/s41467-019-12683-8 · PMCID: PMC6820800	CC BY 4.0	"Kollmer M et al. (2019), Nature Communications, CC BY 4.0"
`kollmer2019-fig2.png`	Fig 2: Cryo-EM micrograph of fibril morphologies I/II (a), side view of reconstructed 3D map (b), atomic model with density fit (c–e)	Same paper as above	Same	CC BY 4.0	"Kollmer M et al. (2019), Nature Communications, CC BY 4.0"

Molecular structures — PDB entries (kept)

PDB coordinate files are public domain per wwPDB policy (https://www.wwpdb.org/about/pdb-data-use). Cite the deposition paper when displaying.

File	Structure	Deposition authors	Method / resolution	Paper
`5OQV.pdb`	Near-atomic fibril structure of complete Aβ(1–42), in-vitro assembled	Gremer L, Schölzel D, Schenk C, Reinartz E, Labahn J, Ravelli RBG, Tusche M, Lopez-Iglesias C, Hoyer W, Heise H, Willbold D, Schröder GF	Cryo-EM, 4.0 Å	Gremer L et al. "Fibril structure of amyloid-β(1–42) by cryo-electron microscopy." Science. 2017;358:116–119
`6SHS.pdb`	Aβ fibril morphology I — purified from Alzheimer's disease brain tissue (patient-derived)	Kollmer M, Fändrich M	Cryo-EM, 4.4 Å	Kollmer M et al. Nat Commun. 2019;10:4760 (CC BY 4.0 — matches fig1/fig2 above; same structure)
`5O3L.pdb`	Paired helical filament of tau from Alzheimer's disease brain	Fitzpatrick AWP, Falcon B, He S, Murzin AG, Murshudov G, Garringer HJ, Crowther RA, Ghetti B, Goedert M, Scheres SHW	Cryo-EM, 3.4 Å	Fitzpatrick AWP et al. "Cryo-EM structures of tau filaments from Alzheimer's disease." Nature. 2017;547:185–190
`6NWP.pdb`	Tau filament, chronic traumatic encephalopathy type I (NOT AD — alternate tau fold, higher resolution)	Falcon B, Zivanov J, Zhang W, Murzin AG, Garringer HJ, Vidal R, Crowther RA, Newell KL, Ghetti B, Goedert M, Scheres SHW	Cryo-EM, 2.3 Å	Falcon B et al. "Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules." Nature. 2019;568:420–423

Rejected candidates (not kept)

Candidate	Why rejected
Cerebral amyloid angiopathy Aβ IHC series (Wikimedia Commons, user "Patho")	Shows Aβ in vessel walls (angiopathy), not parenchymal plaques; subject mismatch for the plaque panel
Kollmer 2019 Fig 4 (polymorphism scatter plot)	Quantitative data chart, not imagery; not needed
Gremer 2017 (5OQV) paper figures	Science 2017 — not open access; figures not reusable (PDB coordinates are public domain, which is why 5OQV.pdb itself was kept)
Fitzpatrick 2017 (5O3L) paper figures	Nature 2017 — not open access; same treatment as above
"Neuropathological features of AD" style composite diagrams from non-OA reviews	License unclear; used the CC BY 3.0 IJMS figure instead

Notes for the graphics build

Best plaque IHC: abeta-tau-ad.tif (CC0, zero restrictions). Tau IHC alternative: tau-tangles-hippocampus.jpg (CC BY-SA 3.0 — share-alike applies to derivatives; prefer the CC0 file if only one is used).
Best fibril EM: kollmer2019-fig1.png (real TEM/SEM of brain-derived fibrils, CC BY 4.0). Molecular model: kollmer2019-fig2.png panels or render from 6SHS.pdb directly.
PDB files can be rendered with PyMOL/ChimeraX for custom fibril views; all public domain.
If the site displays these, include the attribution lines above adjacent to each image.

| elife2026-tau-cryoEM-fig1.jpg | Fig 1: Electron cryo-microscopy (cryo-EM) analysis of phosphomimetic tau filaments — panel B is a raw cryo-EM micrograph of tau filaments (100 nm scale bar); panels C–E show 2D class averages and atomic models | eLife 2026 (phosphomimetic tau assembly paper), PMCID: PMC13189620 | https://doi.org/10.7554/eLife.104778 (verify) · PMCID: PMC13189620 | CC BY 4.0 | "eLife (2026), CC BY 4.0" |