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Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.
Sourced imagery — caloric-restriction academic infographics
Compiled 2026-10-10. Everything below is real, openly licensed scientific imagery/data. No fabricated content.
Molecular structures — PDB entries (kept)
PDB coordinate files are public domain per wwPDB policy (https://www.wwpdb.org/about/pdb-data-use). All three were rendered in-house from the coordinates (CA-trace cartoons); the renderings are original.
| File | Structure | Deposition paper | Method / resolution |
|---|---|---|---|
sourced/4CFH.pdb → sourced/pdb-4CFH-ampk.png |
Mammalian AMPK (alpha-beta-gamma heterotrimer) | Xiao B, Sanders MJ, Underwood E, et al. "Structure of mammalian AMPK and its regulation by ADP." Nature. 2011 | X-ray, 3.24 Å |
sourced/4JT5.pdb → sourced/pdb-4JT5-mtor.png |
mTOR kinase bound to mLST8 | Yang H, Rudge DG, Koos JD, et al. "mTOR kinase structure, mechanism and regulation." Nature. 2013 | X-ray, 3.45 Å |
sourced/4I5I.pdb → sourced/pdb-4I5I-sirt1.png |
SIRT1 catalytic domain bound to NAD and an EX527 analog | Zhao X, Allison D, Condon B, et al. "The 2.5 Å crystal structure of the SIRT1 catalytic domain..." J Med Chem. 2013 | X-ray, 2.5 Å |
Published figures (kept)
All from a paper cited in the review HTML (reviews/caloric-restriction.html), verified CC BY 4.0
via the article page ("Open Access article distributed under the terms of the Creative Commons Attribution
License (https://creativecommons.org/licenses/by/4.0)").
| File | What it shows | Source paper | DOI / PMCID | Figure | License | Required attribution line |
|---|---|---|---|---|---|---|
sourced/jcs-Fig7BC-ragc1.png |
Confocal micrographs: RAGC-1::FLAG (red) and DNA (blue) in control vs dietary-restricted (eat-2) C. elegans; DR excludes the mTORC1 activator RAGC-1 from the nucleus | Charar C, Metsuyanim-Cohen S, Bar DZ. "Lamin regulates the dietary restriction response via the mTOR pathway in Caenorhabditis elegans." J Cell Sci. 2021;134(17):jcs258428 | doi:10.1242/jcs.258428 · PMCID: PMC8445603 | Fig. 7, panels B–C (cropped) | CC BY 4.0 | "Charar C, Metsuyanim-Cohen S, Bar DZ (2021), Journal of Cell Science 134(17):jcs258428, doi:10.1242/jcs.258428, CC BY 4.0, Fig. 7 (cropped)" |
sourced/jcs-Fig1A-worms.png |
Stereomicroscope images: dietary-restricted (eat-2) worms are smaller; lmn-1 RNAi restores size | Same paper as above | Same | Fig. 1, panel A (cropped) | CC BY 4.0 | "Charar C, Metsuyanim-Cohen S, Bar DZ (2021), Journal of Cell Science 134(17):jcs258428, doi:10.1242/jcs.258428, CC BY 4.0, Fig. 1 (cropped)" |
sourced/jcs-Fig2A-oilred.png |
Oil Red O staining: DR (eat-2) worms store less fat; lamin knockdown raises it | Same paper as above | Same | Fig. 2, panel A (cropped) | CC BY 4.0 | "Charar C, Metsuyanim-Cohen S, Bar DZ (2021), Journal of Cell Science 134(17):jcs258428, doi:10.1242/jcs.258428, CC BY 4.0, Fig. 2 (cropped)" |
Figure files were downloaded from the publisher via the PMC image CDN
(e.g. https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cf1/8445603/…/joces-134-258428-g7.jpg); crops are marked "(cropped)".
Rejected candidates (not kept)
| Candidate | Why rejected |
|---|---|
| Wei CZ et al. (2026), Communications Biology, Fig. 3 (NeuN/8-OHdG immunofluorescence, Golgi-stained CA1 neurons) | CC BY 4.0, but the paper is not cited in this review's HTML; replaced with cited-paper figures to stay within the brief's source rule |
| Dong R et al. (2026), Signal Transduction and Targeted Therapy, Fig. 6 (nutrient-sensing network diagram) | CC BY 4.0, but the paper is not cited in this review's HTML; replaced with the cited JCS RAGC-1 panel |
| Wikimedia Commons C. elegans micrographs (e.g. "Caenorhabditis elegans under a light microscope 01.jpg") | CC BY-SA 4.0 — share-alike excluded by the brief |
| Mattison JA et al. (2017), Nat Commun (PMCID: PMC5247583, rhesus monkey CR study, cited in review) | CC BY, but all figures are quantitative charts (mortality/bodyweight curves); no micrographs |
| Civitarese AE et al. (2007), PLoS Med (PMCID: PMC1808482, human muscle CR study, cited in review) | CC BY, but all figures are charts; no electron micrographs |
NCBI OA utility (oa.fcgi) |
Retired (HTTP 404); used Europe PMC fullTextXML + publisher/PMC CDN instead |
Direct europepmc.org/articles/PMC…/bin/… image download |
HTTP 403; used the PMC image CDN URLs instead |
Notes for the graphics build
- No suitable CC0/CC-BY human CR micrographs were found among the review's cited papers; the worm (C. elegans) DR model panels above are the closest openly licensed cellular-scale imagery and are labelled as such on the graphics.
- PDB renderings are original CA-trace cartoons; coordinates are public domain, so no license restriction applies.
- If the site displays these, include the attribution lines above adjacent to each image.