Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.

Sourced imagery — cancer-atavism academic infographics

Compiled 2026-10-10. All figures come from papers cited in reviews/cancer-atavism.html, verified CC BY via Europe PMC and the PMC article pages. No fabricated content.

Published figures (kept)

Trigos AS, Pearson RB, Papenfuss AT, Goode DL. "Somatic mutations in early metazoan genes

disrupt regulatory links between unicellular and multicellular genes in cancer."

Journal: eLife 8:e40947 (2019). DOI: 10.7554/eLife.40947. PMCID: PMC6402835. License: CC BY.
Attribution line on graphic: "Trigos AS et al. (2019), eLife 8:e40947, CC BY. Fig. N."

File	Figure	What it shows
`sourced/elife-phylostrata-tree.jpg`	Fig. 1—figure supplement 2	Phylogenetic tree of the 16 gene phylostrata (1 = cellular organisms … 16 = Homo sapiens)
`sourced/elife-EM-enrichment.jpg`	Fig. 1	Recurrent CNAs and point mutations across phylostrata: enrichment peaks in early-metazoan genes, depleted in mammal-specific genes
`sourced/elife-GRN-top.png`	Fig. 2, panels A–D (cropped)	Point mutations in regulator genes linking unicellular and multicellular subnetworks; network diagram with genes colored by age (UC/EM/MM)

Figure files downloaded from the PMC image CDN (e.g. https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3480/6402835/b8ce567dcf1e/elife-40947-fig1-figsupp2.jpg); the Fig. 2 crop is marked "(cropped)".

Vainshelbaum NM, Giuliani A, Salmina K, Pjanova D, Erenpreisa J. "The Transcriptome and

Proteome Networks of Malignant Tumours Reveal Atavistic Attractors of Polyploidy-Related

Asexual Reproduction."

Journal: International Journal of Molecular Sciences 23(23):14930 (2022). DOI: 10.3390/ijms232314930. PMCID: PMC9736112. License: CC BY 4.0 (verified on the article page: "distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license").

File	Figure	What it shows
`sourced/ijms-STRING-ancient.jpg`	Fig. 3	STRING protein-interaction network of 1st/2nd-phylostrata gametogenesis-related genes expressed in tumors, enriched for cell cycle, meiosis, DNA repair, recombination
`sourced/ijms-ploidy-tumours.jpg`	Fig. 4	Phylostratigraphic distribution of ploidy-upregulated genes in 17 TCGA tumor types; ancient phylostrata dominate
`sourced/ijms-melanoma-proteome.jpg`	Fig. 7, panel A (cropped)	Coexpression network of gametogenesis-related proteins in 142 late-stage melanoma proteomes

Figure files downloaded from the PMC image CDN (e.g. https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5eb/9736112/bb80cb276fe9/ijms-23-14930-g003.jpg).

Rejected candidates (not kept)

Candidate	Why rejected
Wei CZ et al. (2026) / Dong R et al. (2026) figures	From a different page's sourcing; not relevant to atavism
Wikimedia Commons choanoflagellate / Capsaspora micrographs (image search results)	Licenses unclear or CC BY-SA (share-alike excluded); no verifiably CC0/CC-BY specimen found
iNaturalist / microscopy-forum choanoflagellate images	Unknown or incompatible licenses; not cited papers
TRACERx lung cancer papers (PMCID: PMC10115649, CC BY, cited in review)	Figures are phylogeny diagrams and charts only; no micrographs or gene-age content relevant here
PMC11057133 (metazoan gene regulatory networks, CC BY, cited)	Network/co-expression heatmaps overlap the two kept sources; kept sources cover the same evidence more directly

Notes

The atavism review's cited literature is dominated by genomic/phylostratigraphic analyses; the real evidence base is computational, so the graphics use published figures from those analyses rather than fabricated micrographs. Both kept papers are explicitly about the unicellular/multicellular gene-age hypothesis.
If the site displays these, include the attribution lines printed on the graphics adjacent to each image.