Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.

Sourced imagery — cancer-stem-cell-hierarchy academic infographics

Compiled 2026-10-10. All figures come from papers cited in reviews/cancer-stem-cell-hierarchy.html, verified CC BY 4.0 via Europe PMC and the PMC article pages. No fabricated content.

Published figures (kept)

Dirkse A, Golebiewska A, Buder T, et al. "Stem cell-associated heterogeneity in

Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment."

Journal: Nature Communications 10:1619 (2019). DOI: 10.1038/s41467-019-09853-z. PMCID: PMC6467886. License: CC BY 4.0 ("This article is licensed under a Creative Commons Attribution 4.0 International License").

File	Figure	What it shows
`sourced/gbm-Fig4A-IF.png`	Fig. 4, panel A (cropped)	Adherent GBM cells in stem-cell (Undiff_N) vs differentiation (Diff_N) conditions: Nestin, Vimentin, β-III-Tubulin immunofluorescence
`sourced/gbm-Fig2D-states.png`	Fig. 2, panel D (cropped)	Sorted GBM subpopulations reconstitute the original phenotypic mix over days — states are not fixed
`sourced/gbm-Fig2E-network.png`	Fig. 2, panel E (cropped)	Observed state-transition network between GBM subpopulations: non-hierarchical, bidirectional transitions

Figure files downloaded from the PMC image CDN (e.g. https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1b9/6467886/4a7cab408d07/41467_2019_9853_Fig4_HTML.jpg).

Fumagalli A, Oost KC, Kester L, et al. "Plasticity of Lgr5-Negative Cancer Cells Drives

Metastasis in Colorectal Cancer."

Journal: Cell Stem Cell 26(4):570–582 (2020). DOI: 10.1016/j.stem.2020.02.008. PMCID: PMC7118369. License: CC BY 4.0 ("This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)").

File	Figure	What it shows
`sourced/csc-Fig4A-organoids.png`	Fig. 4, panel A (cropped)	Time course: sorted Lgr5− cancer cells forming organoids; Lgr5+ stem-like cells reappear by day 7 — hierarchy re-forms from differentiated cells

Figure file downloaded from the PMC image CDN (https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55b1/7118369/fe66a6232f5a/gr4.jpg).

Rejected candidates (not kept)

Candidate	Why rejected
Zomer A et al. (2013), Stem Cells, PMC3744756 ("Intravital imaging of cancer stem cell plasticity in mammary tumors")	PMC page states CC Attribution 2.5 "which does not permit commercial exploitation" — excluded as a licensing restriction beyond plain CC BY
Dirkse et al. Fig. 2 panels A–C, F–H; Fig. 4 panels F–G (charts)	Charts without imaging content; kept panels cover the plasticity evidence
Dirkse et al. Fig. 1 (flow cytometry), Fig. 3 (hypoxia adaptation)	Overlaps kept panels; kept panels show reversible states more directly

Notes

The Fumagalli et al. organoid time-course figure is the most direct published evidence for the reviewed claim (differentiated cells re-forming the hierarchy); the GBM figures show reversible state transitions at molecular/cellular scale.
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