Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.

Sourced imagery — cancer-stem-cell academic infographics

Compiled 2026-10-10. All figures come from papers cited in reviews/cancer-stem-cell.html, verified CC BY / CC BY 4.0 via Europe PMC and the PMC article pages. No fabricated content.

Published figures (kept)

Fumagalli A, Oost KC, Kester L, et al. "Plasticity of Lgr5-Negative Cancer Cells Drives

Metastasis in Colorectal Cancer."

Journal: Cell Stem Cell 26(4):570–582 (2020). DOI: 10.1016/j.stem.2020.02.008. PMCID: PMC7118369. License: CC BY 4.0 ("This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)").

File	Figure	What it shows
`sourced/csc-Fig1B-confocal.png`	Fig. 1, panel B (cropped)	Confocal images of CRC organoids: Lgr5+ stem-like cells (green) among RFP-labeled cancer cells; diphtheria-toxin ablation of Lgr5+ cells
`sourced/csc-Fig1D-ablation.png`	Fig. 1, panel D (cropped)	Primary tumors and livers after vehicle vs diphtheria-toxin treatment: ablation of Lgr5+ cells prevents tumor growth and metastasis
`sourced/csc-Fig2ABC-intravital.png`	Fig. 2, panels A–C (cropped)	Time-lapse intravital microscopy: the majority of cells escaping primary tumors are Lgr5−

Figure files downloaded from the PMC image CDN (e.g. https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55b1/7118369/af6dfbffb2cd/gr1.jpg).

Cañellas-Socias A, Cortina C, Hernando-Momblona X, et al. "Metastatic recurrence in

colorectal cancer arises from residual EMP1+ cells."

Journal: Nature 604:277–283 (2022). DOI: 10.1038/s41586-022-05402-9. PMCID: PMC7616986. License: CC BY 4.0 ("This work is licensed under a BY 4.0 International license"). The Europe PMC fullTextXML for this article carries no <fig> records (Nature author-manuscript format), so figure URLs were taken from the PMC article page's Images footnote.

File	Figure	What it shows
`sourced/nature-Fig3H-invasion.png`	Fig. 3, panel H (cropped)	Emp1-TOM lineage tracing: Emp1+ high-relapse cells at tumor invasion fronts and core
`sourced/nature-Fig3S-organoid.png`	Fig. 3, panel S (cropped)	Tumor organoid: Emp1+ high-relapse cells (red) alongside Lgr5+ stem-like cells (green)

Figure files downloaded from the PMC image CDN (https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cc7/7616986/.../EMS181817-f003.jpg).

Rejected candidates (not kept)

Candidate	Why rejected
Fumagalli et al. Fig. 1A (mouse model schematic)	Method diagram, not real data
Fumagalli et al. Fig. 1F (heatmap), Fig. 2E–I (charts)	Charts without imaging content
PMC7118369 graphical abstract	Redundant with kept panels
PMC13600930 (ZFP36L2, Nature 2026, CC BY, cited)	Mostly single-cell RNA-seq charts; kept lineage-tracing sources cover stem-cell evidence more directly

Notes

The Lgr5/lineage-tracing figures are the closest openly licensed real imagery to the reviewed claim; the graphics use them plus clearly-labeled schematics for the ranking.
If the site displays these, include the attribution lines printed on the graphics adjacent to each image.