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Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.
Sourced imagery — checkpoint-exhaustion-tumor-evasion academic infographics
Compiled 2026-10-10. Everything below is real, openly licensed scientific imagery/data. No fabricated content.
Images / data used
| File | What it shows | Source | DOI / PMCID | License | Attribution line printed on graphic |
|---|---|---|---|---|---|
fig1i-final.jpg |
Fig 1i (cropped): immunofluorescence of recurrent glioblastoma tissue (GBM.rec vs GBM.pembro) — DAPI (blue), CD14 (red), CD4 (cyan), CD8 (grey); 40 µm scale bar in original. From "Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome immunosuppression in recurrent glioblastoma". | Lee AH, Sun L, Mochizuki AY, Reynoso JG, Orpilla J, Chow F, Kienzler JC, Everson RG, Nathanson DA, Bensinger SJ, Liau LM, Cloughesy T, Hugo W, Prins RM. Nature Communications 12:6532 (2021) | doi:10.1038/s41467-021-26940-2 · PMCID: PMC8626557 | CC BY 4.0 | "Lee AH et al., Nature Communications (2021) — Fig. 1i (cropped), CC BY 4.0" |
tcell-sem.jpg |
"Healthy Human T Cell" — scanning electron micrograph of a human T lymphocyte from a healthy donor | NIAID (U.S. National Institute of Allergy and Infectious Diseases), via Wikimedia Commons | — (no paper) | Public domain (U.S. federal government work) | "NIAID, public domain (via Wikimedia Commons)" |
4ZQK.pdb → pd1-pdl1-4ZQK.png, pd1-pdl1-interface.png |
Crystal structure of the PD-1/PD-L1 complex (PD-L1 chain A, PD-1 chain B), rendered as ribbon cartoons with the page's own renderer; second view colored by chain | RCSB PDB entry 4ZQK | — | Public domain (wwPDB data-use policy) | "Rendered from public-domain PDB coordinates · PDB 4ZQK (PD-1/PD-L1 complex)" |
Rejected candidates
| Candidate | Why rejected |
|---|---|
| Nat Commun 2021 Fig 1 (full) and Fig 6 (Lee et al.) | Full-figure panels are mostly quantitative (flow cytometry, violin plots, heatmaps, chord diagrams); kept only the microscopy crop (Fig 1i) |
| JEM 2026 IRF8 exhaustion figures (doi:10.1084/jem.20252115, PMC13285691) | All panels are flow-cytometry/violin plots — quantitative charts, not imagery |
| PNAS 2019 PD-1+ Treg figures (doi:10.1073/pnas.1822001116, PMC6525547) | License is CC BY-NC-ND 4.0 — does not meet the CC0/CC-BY-only rule |
| "T Lymphocyte - NIAID.jpg" (colorized, CC BY 2.0) | Used the public-domain NIAID SEM instead (zero restrictions) |