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Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.
Sourced imagery — chromatin-dysregulation-cancer academic infographics
Compiled 2026-10-10. Everything below is real, openly licensed scientific imagery/data. No fabricated content.
Images / data used
| File | What it shows | Source | DOI / PMCID | License | Attribution line printed on graphic |
|---|---|---|---|---|---|
nucleosome-1AOI-side.png, nucleosome-1AOI-top.png |
Histone octamer of the nucleosome core particle (chains A–H), rendered as ribbon cartoons with the page's own renderer; colored by histone type (H3 cyan, H4 violet, H2A amber, H2B green) | RCSB PDB entry 1AOI (Luger K, Mäder AW, Richmond RK, Sargent DF, Richmond TJ. Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature 389:251–260, 1997) | — | Public domain (wwPDB data-use policy) | "Rendered from public-domain PDB coordinates · PDB 1AOI (nucleosome core particle, Luger et al., Nature 1997)" |
fig3d-crop.jpg |
Fig 3d (cropped): senescence-associated β-galactosidase staining of primary human myoepithelial cells after targeted DNA hypermethylation (dCas9 3A3L) vs controls. From "Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors". | Saunderson EA, Stepper P, Gomm JJ, Hoa L, Morgan A, Allen MD, Jones JL, Gribben JG, Jurkowski TP, Ficz G. Nature Communications 8:1450 (2017) | doi:10.1038/s41467-017-01078-2 · PMCID: PMC5684409 | CC BY 4.0 | "Saunderson EA et al., Nature Communications (2017) — Fig. 3d (cropped), CC BY 4.0" |
fig2e-crop.jpg |
Fig 2e (cropped): H&E (top row) and CK19 immunohistochemistry (bottom row) of mouse pancreas showing acinar-to-ductal metaplasia after transient in vivo reprogramming. From "In vivo reprogramming drives Kras-induced cancer development". | Shibata H, Komura S, Yamada Y, Sankoda N, Tanaka A, Ukai T, Kabata M, Sakurai S, Kuze B, Woltjen K, Haga H, Ito Y, Kawaguchi Y, Yamamoto T, Yamada Y. Nature Communications 9:2509 (2018) | doi:10.1038/s41467-018-04449-5 · PMCID: PMC5970190 | CC BY 4.0 | "Shibata H et al., Nature Communications (2018) — Fig. 2e (cropped), CC BY 4.0" |
Rejected candidates
| Candidate | Why rejected |
|---|---|
| Nat Commun 2017 Fig 1/2/4/5 (Saunderson et al.) | Mostly schematics, EPIC-array scatter plots, PCA plots — no usable microscopy |
| Nat Commun 2019 BRD9 paper Figs 1–5 (PMC6479050) | Panels are CRISPR screens, mass-spec, western blots, heatmaps — no microscopy imagery |
| Nat Commun 2021 DMRT1 paper Fig 3 (PMC8377058) | Histology present but largely redundant with the chosen Shibata pancreas histology |
| PNAS 2005 / 2019, JCI, Cancer Discovery figures in the review | Europe PMC full-text XML returned HTTP 500 (PNAS, JCI, Cancer Discovery) so licenses could not be verified; excluded rather than assumed |