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Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.
Sourced imagery — cytokine-storm-covid-driver academic infographics
Compiled 2026-10-10. Everything below is real, openly licensed scientific imagery/data. No fabricated content.
Images / data used
| File | What it shows | Source | DOI / PMCID | License | Attribution line printed on graphic |
|---|---|---|---|---|---|
il6-1ALU-side.png, il6-1ALU-top.png |
Interleukin-6 (four-helix-bundle cytokine), rendered as ribbon cartoons with the page's own renderer; two views | RCSB PDB entry 1ALU (Somers W, Stahl M, Seehra JS. 1.9 Å crystal structure of interleukin 6: implications for a novel function of the N-terminal region. EMBO J 16:989–995, 1997) | — | Public domain (wwPDB data-use policy) | "Rendered from public-domain PDB coordinates · PDB 1ALU (IL-6, Somers et al., EMBO J 1997)" |
fig2e-crop.jpg |
Fig 2E (cropped): immunofluorescence of human lung epithelial cells, mock vs SARS-CoV-2 infected — viral N protein (green), IL-6 mRNA (red), DAPI (blue). From "SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation". | Thorne LG, Reuschl AK, Zuliani-Alvarez L, Whelan MVX, Turner J, Noursadeghi M, Jolly C, Towers GJ. The EMBO Journal 40:e107826 (2021) | doi:10.15252/embj.2021107826 · PMCID: PMC8209947 | CC BY 4.0 | "Thorne LG et al., The EMBO Journal (2021) — Fig. 2E (cropped), CC BY 4.0" |
fig2a-crop.jpg |
Fig 2A (cropped): immunofluorescence showing NF-κB p65 nuclear translocation in SARS-CoV-2 infected lung epithelial cells — N protein (green), NF-κB protein (red). Same paper. | Thorne LG et al. The EMBO Journal 40:e107826 (2021) | doi:10.15252/embj.2021107826 · PMCID: PMC8209947 | CC BY 4.0 | "Thorne LG et al., The EMBO Journal (2021) — Fig. 2A (cropped), CC BY 4.0" |
Rejected candidates
| Candidate | Why rejected |
|---|---|
| JEM 2022 Fig 1A chest CT (doi:10.1084/jem.20220131, PMC9206114) | Anatomical-scale clinical imaging; the cellular scene prioritizes cellular-scale data (rest of the figure is PCA/pedigrees) |
| PNAS 2022 IFN autoantibody figures (doi:10.1073/pnas.2200413119, PMC9173764) | All panels are relative-risk/IFR charts — quantitative, not imagery |
| JEM 2023 MyD88/IRAK-4 figures (doi:10.1084/jem.20220170, PMC9998661) | Panels are pedigrees, OR plots, transcriptome plots — no usable microscopy |
| Front Immunol 2021/2024 cytokine figures (PMC8696010, PMC10987806) | All panels are cytokine-profile charts — quantitative, not imagery |