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Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.
Sourced imagery — epigenetic-field-cancerization academic infographics
Compiled 2026-10-10. Everything below is real, openly licensed scientific imagery/data. No fabricated content.
Images / data used
| File | What it shows | Source | DOI / PMCID | License | Attribution line printed on graphic |
|---|---|---|---|---|---|
dnmt1-4WXX-side.png, dnmt1-4WXX-top.png |
DNA methyltransferase 1 (chain A), rendered as ribbon cartoons with the page's own renderer; two views | RCSB PDB entry 4WXX (Song J, Rechkoblit O, Bestor TH, Patel DJ. Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science 331:1036–1040, 2011) | — | Public domain (wwPDB data-use policy) | "Rendered from public-domain PDB coordinates · PDB 4WXX (DNMT1, Song et al., Science 2011)" |
ezh2-ihc-crop.jpg |
Fig 5a (cropped): EZH2 immunohistochemistry of cervical tissue across disease stages — Normal, Low Grade (CIN1), High Grade (CIN3), carcinoma. From "A polycomb-mediated epigenetic field defect precedes invasive cervical carcinoma". | Wijetunga NA, Ben-Dayan M, Tozour J, Burk RD, Schlecht NF, Einstein MH, Greally JM. Oncotarget 7:62133–62149 (2016) | doi:10.18632/oncotarget.11390 · PMCID: PMC5308716 | CC BY 2.5 | "Wijetunga NA et al., Oncotarget (2016) — Fig. 5a (cropped), CC BY 2.5" |
he-colon-crop.jpg |
Fig 5a (cropped): micrographs at 200× of hematoxylin-eosin stained colon mucosa. From "Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancer". | Alonso S, Dai Y, Yamashita K, Horiuchi S, Dai T, Matsunaga A, Sánchez-Muñoz R, Bilbao-Sieyro C, Díaz-Chico JC, Chernov AV, Strongin AY, Perucho M. Oncotarget 6:3420–3431 (2015) | doi:10.18632/oncotarget.2852 · PMCID: PMC4413663 | CC BY 2.5 | "Alonso S et al., Oncotarget (2015) — Fig. 5a (cropped), CC BY 2.5" |
Rejected candidates
| Candidate | Why rejected |
|---|---|
| Oncotarget 2016 Figs 1–4 (Wijetunga et al.) | K-means clustering heatmaps, TCGA validation plots — quantitative charts, not imagery |
| Oncotarget 2015 Figs 1–4, 6 (Alonso et al.) | Methylation/mutation association plots, bisulfite sequencing tracks — quantitative, not imagery |
| eLife 2014 ZNF304 figures (doi:10.7554/eLife.02313, PMC3949416) | Reporter schematics, RNAi screen bar charts, qRT-PCR — no usable microscopy |
| PNAS 2016/2018, JCI figures in the review | Europe PMC full-text XML returned HTTP 500, so licenses could not be verified; excluded rather than assumed |