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Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.

SOURCES — microbiome-master-regulator (Track 2, academic)

All imagery is openly licensed (CC0, CC-BY, or public domain). No CC BY-SA or non-open figures used. PDB coordinates are public domain (wwPDB); structures rendered in-house with PyMOL 3.2.

microbiome-master-regulator-molecular-cascade.png

1. Full-length C. difficile toxin B (PDB 6OQ5) — rendered in-house (cartoon, green).
2. Paper: Chen P, Lam KH, Liu Z, Mindlin FA, Chen B, et al. "Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs." Nat Struct Mol Biol (2019).
3. DOI: 10.1038/s41594-019-0268-0 · Method: X-ray diffraction · License: public domain (wwPDB coordinates).
4. Attribution line: "Rendered from public-domain PDB coordinates (wwPDB) · PDB 6OQ5 — Chen P et al., Nat Struct Mol Biol (2019)"
5. TcdB Pfam domain architecture diagram — sourced/tcdb-domains.png
6. Author: User Boghog. Source: https://commons.wikimedia.org/wiki/File:Protein_tcdB_pfam_domains.png · License: CC0.
7. Clearly labeled on-graphic as a diagram, not a micrograph.
8. Attribution line: "User Boghog — CC0, via Wikimedia Commons"
9. C. difficile electron micrograph — sourced/cdiff-em.png
10. Author: CDC / Lois S. Wiggs.
11. Source: https://commons.wikimedia.org/wiki/File:Clostridium_difficile_EM.png · License: public domain.
12. Attribution line: "CDC / Lois S. Wiggs — public domain, via Wikimedia Commons"

microbiome-master-regulator-cellular-scene.png

1. Small-intestinal villi histology — sourced/ileum-villi.jpg (same file as page 42)
2. Author: Mikael Häggström, M.D. · License: CC0.
3. Source: https://commons.wikimedia.org/wiki/File:Cross-section_histology_of_small_intestinal_villi_of_the_terminal_ileum.jpg
4. Attribution line: "Mikael Häggström — CC0, via Wikimedia Commons"
5. C. difficile scanning EM (CDC PHIL #6260) — sourced/cdiff-01.jpg
6. Author: CDC / Lois S. Wiggs (PHIL #6260, 2004).
7. Source: https://commons.wikimedia.org/wiki/File:Clostridium_difficile_01.jpg · License: public domain.
8. Attribution line: "CDC / Lois S. Wiggs — public domain, via Wikimedia Commons"

Rejected candidates

• "Clostridium difficile CDC.jpg" — CC BY-SA 4.0 → rejected (license).
• "Clostridium difficile gram stain.jpg" — CC BY-SA 3.0 → rejected (license).
• "Clostridium difficile.jpg" — CC BY-SA 3.0 → rejected (license).
• "Colite da Clostridium difficile.svg" — CC BY-SA 3.0 → rejected (license).
• "Pathogenicity Locus of C. diff.png" — CC BY-SA 3.0 → rejected (license).
• "Archetypical Pathogenicity Locus (PaLoc)…png" — CC BY-SA 4.0 → rejected (license).
• "Clostridioides difficile toxin.png" (CC BY 4.0) — a mechanism diagram; replaced by the CC0 TcdB domain diagram + real EM instead.