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Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.

SOURCES — mtor-central-aging-driver (Track 2, academic)

All imagery is openly licensed (CC0, CC-BY, or public domain). No CC BY-SA or non-open figures used. PDB coordinates are public domain (wwPDB); structures rendered in-house with PyMOL 3.2.

mtor-central-aging-driver-molecular-cascade.png

  1. Human mTOR complex 1 (PDB 6BCX) — rendered in-house (cartoon, marine).
  2. Paper: Yang H, Jiang X, Li B, Yang HJ, Miller M, et al. "Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40." Nature (2017). (PDB 6BCX: cryo-EM structure of human mTORC1, 3.0 Å.)
  3. DOI: 10.1038/nature25023 · Method: electron microscopy · License: public domain (wwPDB coordinates).
  4. Attribution line: "Rendered from public-domain PDB coordinates (wwPDB) · PDB 6BCX — Yang H et al., Nature (2017)"
  5. FKBP12–rapamycin–FRB complex (PDB 1FAP) — rendered in-house (cartoon; rapamycin sticks, magenta).
  6. Paper: Choi J, Chen J, Schreiber SL, Clardy J. "Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP." Science 273:239–242 (1996).
  7. DOI: 10.1126/science.273.5272.239 · Method: X-ray diffraction · License: public domain (wwPDB coordinates).
  8. Attribution line: "Rendered from public-domain PDB coordinates (wwPDB) · PDB 1FAP — Choi J et al., Science (1996)"

mtor-central-aging-driver-cellular-scene.png

  1. Bovine pulmonary artery endothelial cells (fluorescence) — sourced/bpaec-fluor.jpg
  2. Author: Erin Rod. Description: nuclei in blue, actin in green, mitochondria in red.
  3. Source: https://commons.wikimedia.org/wiki/File:Bovine_Pulmonary_Artery_Endothelial_Cells_Fluorescent_Image.jpg · License: CC BY 4.0.
  4. Attribution line: "Erin Rod — CC BY 4.0, via Wikimedia Commons"
  5. Autophagy: diagram and data (Fig 1) — sourced/autophagy-plos.jpg
  6. Paper: Juhasz G, Neufeld TP. "Autophagy: A Forty-Year Search for a Missing Membrane Source." PLoS Biol 4(2):e36 (2006).
  7. DOI: 10.1371/journal.pbio.0040036 · Figure 1: (A) autophagy diagram, (B) EM of autophagic structures in fly fat body, (C) autophagosomes in starved-mouse liver. Panel A is a diagram (clearly part of the published figure); panels B–C are real EM/fluorescence data. Real data dominates the graphic overall (2 PDB renders + this figure + 1 fluorescence image).
  8. Source: https://commons.wikimedia.org/wiki/File:Autophagy_diagram_PLoS_Biology.jpg · License: CC BY 2.5.
  9. Attribution line: "Juhasz G, Neufeld TP, PLoS Biol (2006), Fig 1 — CC BY 2.5, via Wikimedia Commons"

Rejected candidates