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Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.

SOURCES — nad-sirtuin-aging (Track 2, academic)

All imagery is openly licensed (CC0, CC-BY, or public domain). No CC BY-SA or non-open figures used. PDB coordinates are public domain (wwPDB); structures rendered in-house with PyMOL 3.2.

nad-sirtuin-aging-molecular-cascade.png

1. Human SIRT3 + carba-NAD analogue (PDB 3GLS) — rendered in-house (cartoon; ligand sticks).
2. Paper: Jin L, Wei W, Jiang Y, Peng H, Cai J, et al. "Crystal structures of the human SIRT3 in complex with a peptidic inhibitor and carba-NAD." J Biol Chem (2009).
3. DOI: 10.1074/jbc.M109.014928 · Method: X-ray diffraction · License: public domain (wwPDB coordinates).
4. Attribution line: "Rendered from public-domain PDB coordinates (wwPDB) · PDB 3GLS — Jin L et al., J Biol Chem (2009)"
5. Human SIRT1 catalytic domain (PDB 4KXQ) — rendered in-house (cartoon, teal).
6. Paper: Davenport AM, Huber FM, Hoelz A. "Structural and functional analysis of human SIRT1." J Mol Biol (2014).
7. DOI: 10.1016/j.jmb.2013.10.009 · Method: X-ray diffraction · License: public domain (wwPDB coordinates).
8. Attribution line: "Rendered from public-domain PDB coordinates (wwPDB) · PDB 4KXQ — Davenport AM et al., J Mol Biol (2014)"

nad-sirtuin-aging-cellular-scene.png

1. Bovine pulmonary artery endothelial cells (fluorescence) — sourced/bpaec-fluor3.jpg
2. Author: Erin Rod. Description: nuclei in blue, actin in green, mitochondria in red.
3. Source: https://commons.wikimedia.org/wiki/File:Bovine_Pulmonary_Artery_Endothelial_Cells_Fluorescent_Image_3.jpg · License: CC BY 4.0.
4. Attribution line: "Erin Rod — CC BY 4.0, via Wikimedia Commons"
5. Cardiac fibroblast nuclei (fluorescence) — sourced/fibroblast-nucleus.jpg
6. Author: Lorenzo2697. Description: fluorescence micrograph; each blue sector is a cardiac-fibroblast nucleus.
7. Source: https://commons.wikimedia.org/wiki/File:Nucleus_of_cardiac_fibroblasts.jpg · License: CC BY 4.0.
8. Attribution line: "Lorenzo2697 — CC BY 4.0, via Wikimedia Commons"

Rejected candidates

• Yeast Sir2 / NAD-metabolism pathway diagrams on Commons — mostly CC BY-SA or unsourced → rejected (license).
• "SIRT6" render (PDB 3K35 was planned) — SIRT1 (4KXQ) chosen instead as the most-studied mammalian sirtuin; 3K35 not rendered.