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Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.
Sourced imagery — rbp-aggregation-als-ftd academic infographics
Compiled 2026-10-10. Everything below is real, openly licensed scientific imagery/data. No fabricated content.
Page review: reviews/rbp-aggregation-als-ftd.html.
Molecular structures — PDB entries (kept)
PDB coordinate files are public domain per wwPDB policy (https://www.wwpdb.org/about/pdb-data-use). Renders were produced for this page (PyMOL, black-background cartoon style); cite the deposition paper when displaying.
| File | Structure | Deposition authors | Paper |
|---|---|---|---|
pdb/4BS2-tdp43.png |
TDP-43 tandem RNA-recognition motifs in complex with UG-rich RNA | Lukavsky PJ, Daujotyte D, Tollervey JR, Ule J, Stuani C, Buratti E, Baralle FE, Damberger FF, Allain FHT | Lukavsky PJ et al. "Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43." Nat. Struct. Mol. Biol. 2013;20:1443–1449. doi:10.1038/nsmb.2698 |
pdb_new/5W3N-fus-lc.png |
Fibril formed by the FUS low-complexity domain | Murray DT, Kato M, Lin Y, Thurber KR, Hung I, McDermott R, Tycko R | Murray DT et al. "Structure of FUS protein fibrils and its relevance to self-assembly and phase separation of low-complexity domains." Cell. 2017;171:615–627. doi:10.1016/j.cell.2017.08.048 |
Required attribution lines (printed on the graphic): "PDB 4BS2 · Lukavsky PJ et al., Nat. Struct. Mol. Biol. 2013 · public-domain coordinates, rendered for this page" and "PDB 5W3N · Murray DT et al., Cell 2017 · public-domain coordinates, rendered for this page".
Photomicrographs (kept)
| File | What it shows | Source | DOI / PMCID | License | Required attribution line |
|---|---|---|---|---|---|
exc-als-inclusions.png |
p62 / TDP-43 / FUS protein inclusions in sporadic ALS tissue | Kirby J et al., Neuropathol. Appl. Neurobiol. 2013, via Wikimedia Commons | — (figure reused via Commons upload) | CC BY 2.5 | "Kirby J et al., Neuropathol. Appl. Neurobiol. 2013, CC BY 2.5, via Wikimedia Commons" |
exc-motor-neuron.jpg |
Spinal cord motor neuron (the cell type that degenerates in ALS) | Berkshire Community College Bioscience Image Library, via Wikimedia Commons | — (no paper) | CC0 | "Berkshire Community College Bioscience Image Library, CC0, via Wikimedia Commons" |
Honesty note (also captioned on the graphics): inclusions are what microscopes see in affected tissue; they are not a causal proof of the aggregation claim.
Rejected candidates (not kept)
| Candidate | Why rejected |
|---|---|
| Ly et al. 2018, Cell Reports (PMC6082376), Figs 1/2/6 | CC BY-NC-ND 4.0 — not permitted (CC0/CC-BY only). Files deleted |
| ALS-patient MRI / scan imagery (web) | Hard rules: no fabricated or reprinted scans; source licenses unverifiable |