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Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.

Sources — Two-hit vascular dementia (academic track)

All images on the two academic graphics are real, openly-licensed data. PDB coordinates are public domain. Diagrams/schematics are labeled as such on the graphics.

Images used

Molecular cascade

  1. Aβ42 fibril — PDB 5OQV. Near-atomic structure of complete Aβ(1–42) fibrils. Paper: Gremer L et al. (2017), Science. Rendered by us with our own CA-trace tube renderer from public-domain coordinates.

  2. Tau filament — PDB 5O3L. Paired helical filament of tau from Alzheimer's brain. Paper: Fitzpatrick AWP et al. (2017), Nature. Rendered by us with our own CA-trace tube renderer from public-domain coordinates.

  3. The blood–brain barrier (published figure)

  4. Source file: Constituents of the BBB in the capillary.jpg
  5. Paper: Uemura MT, Maki T, Ihara M, Lee VMY, Trojanowski JQ (2020). "Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia." Frontiers in Aging Neuroscience 12:80, doi:10.3389/fnagi.2020.00080.
  6. License: CC BY 4.0 (Wikimedia Commons).
  7. Attribution line on graphic: "Uemura MT et al. (2020), Front Aging Neurosci 12:80, CC BY 4.0."

Cellular scene

  1. Brain vessels and mural cells (published figure)
  2. Source file: Brain vessels and mural cells.jpg
  3. Paper: Uemura MT et al. (2020), Front Aging Neurosci 12:80, doi:10.3389/fnagi.2020.00080.
  4. License: CC BY 4.0 (Wikimedia Commons).
  5. Attribution line on graphic: "Uemura MT et al. (2020), Front Aging Neurosci 12:80, CC BY 4.0."

  6. Brain capillaries (published figure)

  7. Source file: 10.1371 journal.pbio.0050169.g001-O.jpg
  8. Source: figure from Abbott NJ (2006), "Bridging the Blood–Brain Barrier," PLoS Biology (synopsis artwork by Dan Ferber).
  9. License: CC BY 2.5 (Wikimedia Commons).
  10. Attribution line on graphic: "From Abbott NJ (2006), PLoS Biol, CC BY 2.5."
  11. Note: low-resolution source (450×466 px); shown at moderate size, aspect preserved.

  12. "Two accounts, one discriminator" — schematic drawn by us, labeled "Schematic" on the graphic (not experimental data).

Rejected candidates