Return to the scientific review

Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.

Sources — Type 3 diabetes / Alzheimer's (academic track)

All images on the two academic graphics are real, openly-licensed data. PDB coordinates are public domain. Diagrams/schematics are labeled as such on the graphics.

Images used

Molecular cascade (all rendered by us from public-domain PDB coordinates)

  1. Human insulin — PDB 2HIU (NMR structure; model 1 shown). Rendered with our own CA-trace tube renderer.

  2. Insulin receptor ectodomain — PDB 4ZXB (X-ray structure, IRΔβ construct in complex with four Fab molecules; the Fabs are crystallisation aids). Rendered with our own CA-trace tube renderer. The on-graphic caption notes the crystallisation Fabs honestly.

  3. GLUT3 glucose transporter — PDB 4ZWC (X-ray structure, maltose-bound outward-open state). Rendered with our own CA-trace tube renderer.

PDB coordinates are public domain; these panels are our own renders, not reused figures.

Cellular scene

  1. Cortical neurons (micrograph)
  2. Source file: Cortical Neurons, stained.jpg — Nissl-stained mouse brain cortex.
  3. Author: Wikimedia Commons user "Ns takes photos."
  4. License: CC BY 4.0 (Wikimedia Commons).

  5. Attribution line on graphic: "Image: Wikimedia Commons contributor, CC BY 4.0."

  6. Hippocampal neurons (micrograph)

  7. Source file: Hippocampal Neurons, stained.jpg — Nissl-stained mouse hippocampus.
  8. Author: Wikimedia Commons user "Ns takes photos."
  9. License: CC BY 4.0 (Wikimedia Commons).

  10. Attribution line on graphic: "Image: Wikimedia Commons contributor, CC BY 4.0."

  11. "The feedback loop" — schematic drawn by us, labeled "Schematic" on the graphic (not experimental data).

Rejected candidates