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Source and license notes supplied with these plates. Plate inclusion does not add a study to the review or change its evidence rating.
SOURCES — warburg-cancer-driver-academic (Track 2, academic)
Compiled 2026-10-10. Every raster image used in this page's academic graphics, with its source, license and attribution. PDB coordinates are public domain per wwPDB policy (https://www.wwpdb.org/about/pdb-data-use); ribbons were rendered by the Hypothesis Critic team from those coordinates. No fabricated imagery.
Images kept
| File | What it shows | Source / authors | DOI / PMCID | Figure | License | Attribution line |
|---|---|---|---|---|---|---|
glycolysis-normal-vs-cancer-ccby.webp |
Differences in glycolysis pathways between normal cells and cancer cells: (A) normal cell in oxygen, (B) cancer cell (Warburg effect) | Kim S-H, Baek K-H. "Regulation of Cancer Metabolism by Deubiquitinating Enzymes: The Warburg Effect." Int J Mol Sci. 2021;22(12):6173 | doi:10.3390/ijms22126173 · PMCID: PMC8226939 | Fig 1 (normal vs cancer cell panels) | CC BY 4.0 | "Kim S-H, Baek K-H (2021), Int J Mol Sci, CC BY 4.0, via Wikimedia Commons" |
fdg-pet-renal-cc0.jpg |
FDG-PET/CT scan: CT axial, PET axial, fusion and whole-body MIP views of a bone metastasis of kidney cancer; crosshairs mark the lesion | Hg6996, Wikimedia Commons (own work) | — (no paper) | — | CC0 | "CC0 (Hg6996), via Wikimedia Commons" |
reverse-warburg-ccby.jpg |
Diagram of the reverse Warburg effect: cancer-associated fibroblasts undergo glycolysis and feed lactate/amino acids to cancer cells | Wilson R, Solass W, Archid R, Weinreich J, Königsrainer A, Reymond M, Wikimedia Commons (source paper not identified on file page) | — (not identified) | — | CC BY 4.0 | "Wilson R et al., CC BY 4.0, via Wikimedia Commons" |
PDB structures rendered (public domain coordinates)
| PDB | Structure | Deposition authors | Paper | Rendered for |
|---|---|---|---|---|
1I10 |
Human muscle L-lactate dehydrogenase M chain, ternary complex with NADH and oxamate (tetramer) | Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL | Read JA et al. "Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase." Proteins. 2001;43:175–185 | molecular-cascade panel 2 |
3SRD |
Human M2 pyruvate kinase in complex with fructose 1,6-bisphosphate and oxalate | Morgan HP, O'Reilly F, Palmer R, McNae IW, Nowicki MW, Wear M, et al. | Deposition paper (to be published at deposition) | molecular-cascade panel 3 |
Rejected candidates (not used)
| Candidate | Why rejected |
|---|---|
File:PET-CT (FDG) metastasierendes Mammakarzinom (MIP).ogv |
CC BY-SA 3.0 — share-alike license not permitted |
File:PET-CT scanning of lymph node metastases in cancer.jpg |
CC BY-SA 3.0 — share-alike license not permitted |
File:Glycolysis Simple Diagram.jpg (CC BY 4.0) |
Redundant with the Kim & Baek figure, which directly contrasts normal vs cancer cells |
File:Glycolysis skeletal diagram.png (CC BY 4.0) |
Downloaded as backup; not needed once the Kim & Baek figure was placed |
File:Lactate dehydrogenase M4 (muscle) 1I10.png (public domain) |
Third-party ribbon render of 1I10; rendered our own ribbon from PDB coordinates instead |
File:Adenocarcinoma of lung, FNA (5435902375).jpg (CC BY 2.0) |
Cytology smear; the FDG-PET image carries the metabolic story more directly |