{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "DNA folds into loops, domains and compartments. This review separates the effects of specific local folding features from the broader claim that folding is the primary determinant of gene activity.",
  "implications": "The preregistered scope-matched gate is SC3, yielding Γ. SC2 reaches Ζ through independent endogenous boundary edits, allele-resolved human/mouse developmental tests and locus-directed functional rescue, interpreted as architectural contribution rather than a sole switch. SC1 is an existence statement: Β records robust structural observation without pretending existence itself proves regulatory causality. Its empirical reality is well established and is not refuted by this causal ladder.",
  "limitations": "60 primary reports with 11 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}