{
  "completed": true,
  "status": "documented_historical_discovery_and_reconciliation",
  "provider": "Consensus",
  "provider_mode": "Historical browser/connector use as recorded in the source artifacts",
  "local_audit_date": "2026-10-09",
  "primary_comparison_count": null,
  "reported_usage": [],
  "grade_changed": false,
  "score_before": {
    "hsef_level": "Γ",
    "hsef_descriptor": "Mechanistically plausible, partial system support",
    "confidence": "Moderate",
    "confidence_rationale": "56 primary reports examined; 4 selected partial-body examinations. Replication, heterogeneity, shared cohorts, specificity and incomplete correction-body access support Moderate confidence in this bounded adjudication.",
    "rests_on_non_peer_reviewed_work": false,
    "rationale": "Scope-matched SC4 returns Γ for primary initiation/generalization; SC5 separately returns Ε for early clinical contribution. Human genetics and clinical perturbations are considered together and are not re-capped as mere association. Their convergence supports bounded amyloid contribution, while sole/primary initiation and exact pathogenic-species mediation remain unresolved."
  },
  "score_after": {
    "hsef_level": "Γ",
    "hsef_descriptor": "Mechanistically plausible, partial system support",
    "confidence": "Moderate",
    "confidence_rationale": "56 primary reports examined; 4 selected partial-body examinations. Replication, heterogeneity, shared cohorts, specificity and incomplete correction-body access support Moderate confidence in this bounded adjudication.",
    "rests_on_non_peer_reviewed_work": false,
    "rationale": "Scope-matched SC4 returns Γ for primary initiation/generalization; SC5 separately returns Ε for early clinical contribution. Human genetics and clinical perturbations are considered together and are not re-capped as mere association. Their convergence supports bounded amyloid contribution, while sole/primary initiation and exact pathogenic-species mediation remain unresolved."
  },
  "independent_blinded_audit": false,
  "raw_receipts": [
    {
      "path": "deliverables\\hsef_v53_popularity_batch_2026-10-04\\amyloid-cascade\\consensus\\evidence-cards.json",
      "sha256": "4eb4c0e020595dfbc6c713489b4e0305f6b78708171923d8a84a1cfe3df2cb29"
    },
    {
      "path": "deliverables\\hsef_v53_popularity_batch_2026-10-04\\amyloid-cascade\\consensus\\evidence-cards.md",
      "sha256": "7792f1d9707cb9044cc016910e852dfb28453cc32286d1420772a47dcd6dbc04"
    },
    {
      "path": "deliverables\\hsef_v53_popularity_batch_2026-10-04\\amyloid-cascade\\discovery\\consensus-targeted.json",
      "sha256": "064410246d56e30815e98a906ab712ab634a93f4b1307327fa058dfe3e71f969"
    },
    {
      "path": "deliverables\\hsef_v53_popularity_batch_2026-10-04\\amyloid-cascade\\discovery\\consensus.json",
      "sha256": "eb868f4291f9993c5719e1bb7a3ac2f7b464b30d9d8cc0ae75236175d712780c"
    },
    {
      "path": "deliverables\\prepublication-enrichment-2026-10-05\\website-series\\amyloid-cascade\\consensus-browser-links.json",
      "sha256": "605dc9b4b84db9d131184200ca0b8f74a7c6ce5621f35d75439b5834491d2de0"
    }
  ],
  "limitations": "This verifies documented historical use and links the record to the final edition. It adds no primary-source, full-text, independence or verification credit. Original access remains limited to the source-specific record.",
  "existing_primary_reconciliation": {
    "slug": "amyloid-cascade",
    "consensus_used": true,
    "rawproof": [
      "deliverables/prepublication-enrichment-2026-10-05/website-series/amyloid-cascade/consensus-browser.txt",
      "deliverables/prepublication-enrichment-2026-10-05/website-series/amyloid-cascade/consensus-targeted-check.txt",
      "deliverables/prepublication-enrichment-2026-10-05/website-series/amyloid-cascade/consensus-browser-links.json"
    ],
    "reconciliation_existing": "Yes; 11 timeline primary identifiers cross-checked per dated ledger; 1 selected body check plus 10 abstract excerpts; timeline, gaps, access limits documented.",
    "primary_sources_matched": [
      "1671712",
      "16369530",
      "17478722",
      "22784036",
      "22801501",
      "31686034",
      "36449413",
      "37459141",
      "37966285",
      "38381674",
      "40120616"
    ],
    "limitations": "Selected checks are not complete-paper examinations (ledger says 0 complete papers). Raw Consensus is discovery/provenance, not the independently verified passage evidence."
  }
}