{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "Amyloid-beta can interact with microbes in experimental systems. This review asks whether that activity operates in normal brain defense and whether human Alzheimer plaques are a protective response to infection.",
  "implications": "The preregistered weakest-link rule yields Β from SC6. Direct human support for net protective pathogen-centered plaques is localization and ex vivo activity, without functional necessity, temporal demonstration or infection-stratified benefit. SC1–5 have mechanistic or simplified-model support (Γ); neither APP receptor immunity nor clinical antibody efficacy proves the nominal protective mechanism. This grade does not deny in vitro activity or refute all pathogen contributions.",
  "limitations": "61 primary reports with 6 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}