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      "pmid": "19590001",
      "doi": "10.1126/science.1173635",
      "review_source_n": 6,
      "source_type": "primary animal study",
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      "doi": "10.1038/ncomms14063",
      "review_source_n": 8,
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      "doi": "10.1001/jamainternmed.2016.1189",
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    "rationale": "The registered scope-matched human-lifespan gate SC3 returns Γ. SC1 animal survival reaches Ζ and SC4 human function reaches Ε; the candidate unified mechanism SC2 is separately Γ and is not an added necessary clause of the generic exposure claim. All preregistered aggregation sensitivities happen to return Γ."
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  "grade_changed": false,
  "conclusion": "Human lifespan extension remains Γ because animal survival and human physiological/function outcomes do not substitute for human mortality or a validated mortality surrogate. No new sources counted in the original 60-report inventory.",
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