{
  "slug": "cancer-atavism",
  "round": 2,
  "date": "2026-10-14",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "canonical": "consensus_consistency_audit_2026-10-09\\revised\\cancer-atavism\\cancer-atavism.review.md",
  "edition_note": "The 2026-10-09 revision added only the spliced Consensus provenance reconciliation block; a full diff against the 2026-10-08 edition shows no other change. No earlier adversarial approval of this slug exists, so this is its first adversarial adjudication.",
  "level_before": "Γ",
  "level_after": "Γ",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "role_before": "epiphenomenon",
  "role_after": "epiphenomenon",
  "momentum_before": "Decisive work underway",
  "momentum_after": "Mechanistic only",
  "counts": {
    "critical": 0,
    "major": 0,
    "minor": 4,
    "editorial": 1
  },
  "pmids_checked": 59,
  "pmids_failed": 0,
  "dois_checked": 59,
  "dois_failed": 0,
  "retractions": 0,
  "expressions_of_concern": 1,
  "expression_of_concern_detail": "PMID 41986727, Editorial Expression of Concern, Nature 652(8112):E18, April 2026, on Hahn 1999 (PMID 10440377); verified directly and correctly excluded from load-bearing positive evidence",
  "claims_spot_checked": 9,
  "claims_unsupported": 0,
  "findings": [
    {
      "id": "D1",
      "severity": "Minor",
      "location": "AT A GLANCE; M/S/D section; scorecard extended_scoring_MSD.momentum",
      "original": "Momentum: Decisive work underway (artifact names published 2024 mapping, 2022 GOT2 tests and 2026 correction notices, then disclaims any ongoing recruiting trial)",
      "corrected": "Momentum: Mechanistic only, artifact sentence extended to say no running experiment that could cross the next threshold is named",
      "evidence": "framework reserves 'Decisive work underway' for an experiment someone is running that could cross the next threshold; momentum modifies no letter"
    },
    {
      "id": "D2",
      "severity": "Minor",
      "location": "Consensus provenance reconciliation block",
      "original": "The earlier adversarial approval refers to its original edition",
      "corrected": "rescoped: this case carried no earlier adversarial approval when the 9 October 2026 reconciliation was spliced in",
      "evidence": "false template boilerplate; no adversarial record for this slug exists anywhere in the deliverables tree and the earlier edition has neither banner nor approval section"
    },
    {
      "id": "D3",
      "severity": "Minor",
      "location": "REVIEWER NOTES",
      "original": "Expression of Concern PMID10440377 is retained as examined historical context",
      "corrected": "The 1999 report PMID10440377, which carries the 2026 Editorial Expression of Concern PMID41986727, is retained as examined historical context",
      "evidence": "PMID 10440377 is the parent article; PMID 41986727 is the notice, as the evidence card already recorded"
    },
    {
      "id": "D4",
      "severity": "Minor",
      "location": "scorecard final_score.confidence_rationale",
      "original": "density, heterogeneous controls and incomplete access set the confidence, not correctness",
      "corrected": "rationale resting on evidence density and reproducibility alone, with access depth reported separately",
      "evidence": "the framework ties confidence to evidence density and reproducibility, not the reviewer's access depth; re-derived on legitimate grounds the band remains Moderate, so only the basis changed. Historical score_before/score_after snapshots in consensus_validation left as-is.",
      "lead_policy_2026_10_14": "two-step test applied: access depth struck as a determinant, band re-derived from what remained; step 2 keeps Moderate because the review documents substantive evidence-quality and reproducibility concerns (the distinctive coherent-program claim rests on a small set of analyses sharing TCGA data and gene-age assignments with no independent biological replication, against an openly heterogeneous metabolic literature), which are legitimate determinants, and the High band's requirement of extensive independent replication across labs, models and assay modalities is not met"
    },
    {
      "id": "D5",
      "severity": "Editorial",
      "location": "17 lines",
      "original": "lost inter-word spaces: 'ErratumIn: PMIDnot supplied.', Fig1b, Fig4a, Fig4C",
      "corrected": "spaced forms",
      "evidence": "known upstream builder whitespace defect; whitespace-only repair verified, with p53/Yap1/Hand2/beta1/INK4A/CDK4/PP2A/hTERT/GOT2/MCT1/SOX11/SOX4 protected"
    }
  ],
  "rejected_findings": [
    "aggregation: SC3 primacy with mandatory paired SC2/SC3 minimum; all three alternatives reported; the Β sensitivity comes from narrower SC1/SC4 components reported separately; index deviation disclosed",
    "Β/Γ boundary for the nominal: Γ correct without a selective whole-program disruption-and-rescue experiment",
    "causal role epiphenomenon at framework Step 2 correct for the distinctive coherent-program account",
    "competing models at Ε and Δ above the nominal Γ are permitted; the tournament does not set the level",
    "renderer defect printing the nominal as its own 'Best-supported rival': checked, absent (models_evaluated[0] is rank 1, is_nominal false; nominal is rank 4)",
    "reviewer-notes versus spliced-consensus-block contradiction: checked, absent (METHODS AND CONSENSUS CONTRIBUTION already records signed-in Consensus browser use)",
    "three evidence cards record 'ErratumIn: PMID not supplied'; identifiers genuinely absent from retrieved metadata",
    "print/issue vs e-pub year all within plus or minus one",
    "validator warning v5.claim_form: the claim states re-expression plus the consequence that the program drives tumorigenesis, the documented exception"
  ],
  "residual_limitations": [
    "8 sources at partial-body depth, 51 at abstract/status depth; full-text figures (3473 tumours / 386 normals / 17318 age-assigned genes, 364 CRISPR cell lines, 16 matched-normal cohorts) rest on package retrieval receipts",
    "bodies of the 2014, 2019, 2024 and 2026 correction notices were not read",
    "scorecard provenance strings name the generating system 'Codex'; not altered here"
  ],
  "divergent_copies_not_modified": [
    "hsef_v53_popularity_ranks_31_35_2026-10-08\\cancer-atavism\\cancer-atavism.review.md (still carries the uncorrected Momentum value and Expression-of-Concern sentence)"
  ],
  "scorecard_changed": true,
  "scorecard_fields_changed": [
    "extended_scoring_MSD.momentum.value",
    "extended_scoring_MSD.momentum.artifact",
    "extended_scoring_MSD.momentum.justification",
    "final_score.confidence_rationale"
  ],
  "validator": {
    "tool": "hsef-hypothesis-review-v5/tools/validate_review.py",
    "pass": 33,
    "warn": 1,
    "fail": 1,
    "warn_checks": [
      "v5.claim_form"
    ],
    "fail_checks": [
      "v5.lay_summary"
    ],
    "note": "v5.claim_form rejected by standing convention; v5.lay_summary is marked mandatory from v5.4 and does not apply to this v5.3 package"
  },
  "status": "Approved as revised"
}