{
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  "status": "documented_historical_discovery_and_reconciliation",
  "provider": "Consensus",
  "provider_mode": "Historical browser/connector use as recorded in the source artifacts",
  "local_audit_date": "2026-10-09",
  "primary_comparison_count": null,
  "reported_usage": [],
  "grade_changed": false,
  "score_before": {
    "hsef_level": "Γ",
    "hsef_descriptor": "Mechanistically plausible, partial system support",
    "confidence": "High",
    "confidence_rationale": "The evidence base includes multiple independent endogenous lineage and ablation studies, patient-derived systems, human relapse tracking, two randomized human trials, and direct falsification of fixed-state predictions. Confidence reflects the density and reproducibility of that evidence and the stability of this assessment of it, not confidence that the universal proposition is false. Per hsef-framework.md, (Γ, High) reads: the hypothesis is well studied and we are confident current evidence does not yet justify more than mechanistic plausibility with partial system support.",
    "rests_on_non_peer_reviewed_work": false,
    "rationale": "The claim is a six-part conjunction stated across tumour types. The three clauses that carry that cross-tumour scope — rarity (SC2), broad sufficiency (SC3) and irreplaceability (SC6) — all sit at Γ under recorded ceilings: the strongest rarity and serial-reconstitution evidence is transplantation-based and falls under the rubric's xenograft hard rule, and the field-valid endogenous tests of irreplaceability are negative. The three clauses that reach Ε (SC1, SC4, SC5) do so by narrowing to defined tumour contexts, which is what Ε means, so under the prescribed scope-matched rule they are the narrower subclaims reported separately rather than the headline. Stem-like states do causally maintain or reinitiate tumours in defined cancers and stages; that bounded result is reported at Ε in the matrix and is not what the nominal sentence asserts."
  },
  "score_after": {
    "hsef_level": "Γ",
    "hsef_descriptor": "Mechanistically plausible, partial system support",
    "confidence": "High",
    "confidence_rationale": "The evidence base includes multiple independent endogenous lineage and ablation studies, patient-derived systems, human relapse tracking, two randomized human trials, and direct falsification of fixed-state predictions. Confidence reflects the density and reproducibility of that evidence and the stability of this assessment of it, not confidence that the universal proposition is false. Per hsef-framework.md, (Γ, High) reads: the hypothesis is well studied and we are confident current evidence does not yet justify more than mechanistic plausibility with partial system support.",
    "rests_on_non_peer_reviewed_work": false,
    "rationale": "The claim is a six-part conjunction stated across tumour types. The three clauses that carry that cross-tumour scope — rarity (SC2), broad sufficiency (SC3) and irreplaceability (SC6) — all sit at Γ under recorded ceilings: the strongest rarity and serial-reconstitution evidence is transplantation-based and falls under the rubric's xenograft hard rule, and the field-valid endogenous tests of irreplaceability are negative. The three clauses that reach Ε (SC1, SC4, SC5) do so by narrowing to defined tumour contexts, which is what Ε means, so under the prescribed scope-matched rule they are the narrower subclaims reported separately rather than the headline. Stem-like states do causally maintain or reinitiate tumours in defined cancers and stages; that bounded result is reported at Ε in the matrix and is not what the nominal sentence asserts."
  },
  "independent_blinded_audit": false,
  "raw_receipts": [
    {
      "path": "deliverables\\prepublication-enrichment-2026-10-05\\website-series\\cancer-stem-cell\\consensus-browser-links.json",
      "sha256": "0d0555b65f7e7d373e42f2359c9cbf3a3b5688dcde27784c0b702cb86ccd892b"
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    {
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      "sha256": "e3ca63985dbd1c6350c71a7d266f83942cf8ef2281af921a53cddd45f2b55f97"
    },
    {
      "path": "deliverables\\prepublication-enrichment-2026-10-05\\website-series\\cancer-stem-cell\\consensus-pro-links.json",
      "sha256": "824765ea93e60475fa65f94c6ed78876de705ed7e11c8611949a0e64bd033fcf"
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    {
      "path": "deliverables\\prepublication-enrichment-2026-10-05\\website-series\\cancer-stem-cell\\consensus-pro.txt",
      "sha256": "b6db7b616360bbb621979f4d01a7d6bbd6d082bb1394fd0e0f0c25aa076e2951"
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    {
      "path": "deliverables\\prepublication-enrichment-2026-10-05\\website-series\\cancer-stem-cell\\consensus-targeted-check.txt",
      "sha256": "5047b178d377610e8a2b719a6c06f9e3a340f56703f924261920bba806d59612"
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  "limitations": "This verifies documented historical use and links the record to the final edition. It adds no primary-source, full-text, independence or verification credit. Original access remains limited to the source-specific record.",
  "existing_primary_reconciliation": {
    "slug": "cancer-stem-cell",
    "consensus_used": true,
    "rawproof": [
      "deliverables/prepublication-enrichment-2026-10-05/website-series/cancer-stem-cell/consensus-browser.txt",
      "deliverables/prepublication-enrichment-2026-10-05/website-series/cancer-stem-cell/consensus-targeted-check.txt",
      "deliverables/prepublication-enrichment-2026-10-05/website-series/cancer-stem-cell/consensus-browser-links.json"
    ],
    "reconciliation_existing": "Yes, with explicit rejection of later reviews as primary proof; 11 primary identifiers in timeline; selected single-cell/Methods passage checked.",
    "primary_sources_matched": [
      "9212098",
      "12629218",
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    ],
    "limitations": "Consensus paper links alone do not establish body access. Dated addendum describes one selected passage, not complete paper checks."
  }
}