{ "completed": true, "status": "completed_original_source_reconciliation", "provider_mode": "Consensus Pro signed-in browser; observed output and citation link mappings", "queries": [ "https://consensus.app/search/venoplasty-effects-on-multiple-sclerosis/7GNWiP1PQ3CadpOaO4XZhA/" ], "query_record_note": "Exact visible question/response retained privately in raw browser receipt.", "primary_comparison_count": 10, "primary_comparisons": [ { "pmid": "24975855", "doi": "10.1212/WNL.0000000000000638", "source_type": "primary study report", "study_group": "PREMiSe-NCT01450072", "access_depth": "abstract_metadata", "consensus_aspect": "PREMiSe adverse-direction trends are not definitive exacerbation", "result_comparison": "Consensus relied on clinical summaries rather than the requested original and described paradoxical exacerbation too decisively. The bounded original abstract reports nonsignificant between-group new-lesion and relapse trends in a 19-participant randomized phase, plus an exploratory covariance association. Its randomized target-engagement criterion was not achieved. The original body was unavailable this run: abstract-only attribution is explicit, and neither ideal mechanism ablation nor established worsening is claimed.", "original_source": "https://pubmed.ncbi.nlm.nih.gov/24975855/", "source_examination_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-0-17-6500.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-0-6-6500.json" ], "body_receipts": [] }, { "pmid": "30266886", "doi": "10.1212/WNL.0000000000006423", "source_type": "primary study report", "study_group": "PMID30266886", "access_depth": "full_text_partial", "consensus_aspect": "Missing Canadian original and primary clinical endpoint", "result_comparison": "Consensus omitted this requested original and substituted a pooled review. Original Methods/Results were examined: 104 randomized participants, primary MSQOL54 change, secondary disability/relapse/MRI, independent assignment and blinded assessors. Both groups transiently improved; no clinical benefit separated. The planned primary-effect power was only 60%, so small or delayed effects remain bounded rather than excluded.", "original_source": "https://pubmed.ncbi.nlm.nih.gov/30266886/", "source_examination_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-0-17-6500.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-0-6-6500.json" ], "body_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\body-presentation-receipts\\30266886-s0-p0-4-5-6-8.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\body-presentation-receipts\\30266886-s1-p3-6-8-9-10.json" ] }, { "pmid": "29150995", "doi": "10.1001/jamaneurol.2017.3825", "source_type": "primary study report", "study_group": "BraveDreams-NCT01371760", "access_depth": "full_text_partial", "consensus_aspect": "Clinical/MRI hierarchy and actual incomplete engagement", "result_comparison": "Consensus correctly retained 115 RRMS participants and 38/71 restored-flow treated patients. Original Methods show co-primary functional and MRI endpoints, early trial closure at 115 versus amended target300, intention-to-treat and multiplicity adjustment. Original Results include restored flow in 14/37 sham participants and favorable late nominal MRI comparisons that lost adjusted significance. These details limit a complete-blockade interpretation while preserving the negative clinical finding.", "original_source": "https://pubmed.ncbi.nlm.nih.gov/29150995/", "source_examination_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-0-17-6500.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-0-6-6500.json" ], "body_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\body-presentation-receipts\\29150995-s1-p2-3-5-8-11-12-13-14.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\body-presentation-receipts\\29150995-s2-p0-3-14-20-21.json" ] }, { "pmid": "31735108", "doi": "10.1177/1526602819890110", "source_type": "primary study report", "study_group": "BraveDreams-NCT01371760", "access_depth": "full_text_partial", "consensus_aspect": "A genuine positive MRI lead from the same parent", "result_comparison": "Consensus correctly identified the expanded 130-patient analysis and positive lesion-free result, but the evidence is one Brave Dreams parent, not clinical replication. Examined original Methods/Results show added progressive patients, post hoc anatomy grading, exclusion of discordant classifications and positive MRI comparisons. The examined 2020 correction explicitly changes secondary-analysis terminology to post hoc. No numerical-effect change is stated in that correction. Prospective independent clinical validation remains the relevant gap.", "original_source": "https://pubmed.ncbi.nlm.nih.gov/31735108/", "source_examination_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-0-17-6500.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-0-6-6500.json" ], "body_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\body-presentation-receipts\\31735108-s1-p0-12-13-15-16.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\body-presentation-receipts\\31735108-s2-p0-1-3-4.json" ] }, { "pmid": "24119384", "doi": "10.1016/S0140-6736(13)61747-X", "source_type": "primary study report", "study_group": "CANADIAN-DIAGNOSTIC", "access_depth": "abstract_metadata", "consensus_aspect": "Diagnostic-control originals extend the provider coverage", "result_comparison": "Consensus used initial diagnostic papers and an early CIS original, omitting the key sibling-controlled venography study. Its bounded original abstract shows greater-than-50% narrowing similarly common in MS, unaffected siblings and unrelated controls; ultrasound poorly identified catheter narrowing. The companion MRV report is grouped with this parent rather than counted as independent population replication. Anatomical narrowing alone does not establish pathological obstruction.", "original_source": "https://pubmed.ncbi.nlm.nih.gov/24119384/", "source_examination_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-67-69-6500.json" ], "body_receipts": [] }, { "pmid": "28721810", "doi": "10.2174/1567202614666170718095203", "source_type": "primary study report", "study_group": "PMID28721810", "access_depth": "full_text_partial", "consensus_aspect": "Reader reproducibility is a retained positive, with its unit stated", "result_comparison": "Consensus summarized diagnostic reproducibility mainly negatively. The examined original Methods/Results retain substantial agreement between expert local and central readers, particularly for selected criteria. Shared acquired recordings differ from independently reproduced acquisition/physiology; positive reader agreement therefore survives alongside the cross-center specificity challenge.", "original_source": "https://pubmed.ncbi.nlm.nih.gov/28721810/", "source_examination_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-34-51-6500.json" ], "body_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\body-presentation-receipts\\28721810-s1-p0-7-11.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\body-presentation-receipts\\28721810-s2-p3-4-5.json" ] }, { "pmid": "21803799", "doi": "10.1258/phleb.2011.011052", "source_type": "primary study report", "study_group": "PMID21803799", "access_depth": "abstract_metadata", "consensus_aspect": "Balloon-only objective harm without a population-rate claim", "result_comparison": "Consensus appropriately found the jugular-thrombosis case. Its bounded original abstract supports local thrombosis after balloon venoplasty without stenting despite anticoagulation, requiring surgery. This shows possible mechanical injury; it supplies neither a general incidence nor proof that every postprocedure clinical deterioration was caused by treatment.", "original_source": "https://pubmed.ncbi.nlm.nih.gov/21803799/", "source_examination_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-17-25-6500.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-17-34-6500.json" ], "body_receipts": [] }, { "pmid": "23249660", "doi": "10.14712/23362936.2015.12", "source_type": "primary study report", "study_group": "PMID23249660", "access_depth": "abstract_metadata", "consensus_aspect": "Potential fatal embolism is not an observed death", "result_comparison": "Consensus listed fatal pulmonary-embolus hazards among catastrophically attributed stent outcomes. The examined original case reports imaging-confirmed displacement/thrombosis and discusses a potential future fatal embolic event; no fatal pulmonary embolus was observed in this case. Device harm remains real, but speculative hazards are distinguished from observed fatalities.", "original_source": "https://pubmed.ncbi.nlm.nih.gov/23249660/", "source_examination_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-17-25-6500.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-17-34-6500.json" ], "body_receipts": [] }, { "pmid": "23380649", "doi": "10.1177/1352458513475491", "source_type": "primary study report", "study_group": "ITALIAN462", "access_depth": "abstract_metadata", "consensus_aspect": "Events after treatment require attribution and correction bounds", "result_comparison": "Consensus safety wording overgeneralized causal systemic harms. This original reports serious events at variable post-treatment intervals in the same 462-person parent as the clinical report; seven jugular thromboses are mechanically plausible, while a myocardial-infarction death ten weeks later and other systemic events are not all established procedure-caused. The linked harm correction body was blocked403, so corrected numerical details remain unverified. Canadian original-body adjudication separately found its six serious events unrelated, while retaining one local jugular dissection.", "original_source": "https://pubmed.ncbi.nlm.nih.gov/23380649/", "source_examination_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-17-25-6500.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-17-34-6500.json" ], "body_receipts": [] }, { "pmid": "31445091", "doi": "10.1016/j.avsg.2019.05.018", "source_type": "primary study report", "study_group": "PMID31445091", "access_depth": "abstract_metadata", "consensus_aspect": "A selected timeline cannot establish a global 2026 research hiatus", "result_comparison": "Consensus claimed randomized tests ceased entirely and a complete hiatus through late 2026 based on 2019/2020 sources. The selected original wait-list trial provides a completed objective-null/subjective-mixed milestone, not proof of global absence of later trials. Our search-bounded momentum judgment names completed original programs and explicitly makes no universal current registry or regulatory-status claim.", "original_source": "https://pubmed.ncbi.nlm.nih.gov/31445091/", "source_examination_receipts": [ "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-0-17-6500.json", "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\examinations\\original-0-6-6500.json" ], "body_receipts": [] } ], "grade_changed": false, "grade_change_note": "Source-based adjudication; no independent blinded regrade claimed.", "raw_receipts": [ { "path": "deliverables\\hsef_v53_remaining_priority_20_22_2026-10-12\\ccsvi-ms-liberation\\consensus-browser-2026-10-12.json", "sha256": "155bfff3ee064b754271bbd00c3983d71f52bb4fb52cea07872a66684493e409" } ], "independent_blinded_audit": false, "cutoff": "2026-10-12", "completed_utc": "2026-10-12T21:01:19.129057+00:00", "conclusion": "Endpoint hierarchy, experimental scope and original-source limits determine the evidence cards; provider wording does not override them." }