{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used bounded original primary abstract passages/status records and selected original partial-body passages. No complete-abstract or complete-paper audit, or independent scientific peer review, is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "Accessible chromatin predicts regulatory activity, but access alone neither guarantees transcription nor supplies a universal upstream mechanism of competence.",
  "implications": "Overall Γ follows the preregistered primary necessity SC2: strong endogenous remodeler/factor causality exists, but necessity of the measured accessible state itself remains incompletely isolated. SC1 correlation is Β. Broad sufficiency SC3 and universal upstream SC4 are each Β after one-rung falsification downgrades from partial Γ. The alternative aggregation rules would return Β weakest-link and Γ primary/scope-matched.",
  "limitations": "61 primary reports with 6 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}