# Chromatin Accessibility = Transcriptional Competence

Accessible chromatin predicts regulatory activity, but access alone neither guarantees transcription nor supplies a universal upstream mechanism of competence.

Overall Γ follows the preregistered primary necessity SC2: strong endogenous remodeler/factor causality exists, but necessity of the measured accessible state itself remains incompletely isolated. SC1 correlation is Β. Broad sufficiency SC3 and universal upstream SC4 are each Β after one-rung falsification downgrades from partial Γ. The alternative aggregation rules would return Β weakest-link and Γ primary/scope-matched.

Locus sequence, factor identity, cell state, developmental/replication window, dose and observation interval are specified before results. Bulk accessibility and transient local DNA exposure differ. No subset is defined afterward as competent solely because it transcribes, and unresponsive open loci remain in the analysis. Zebrafish early priming and mammalian postreplication restart are both retained without forcing one global direction.