{
  "slug": "chromatin-dysregulation-cancer",
  "round": 2,
  "date": "2026-10-14",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "canonical": "consensus_consistency_audit_2026-10-09\\revised\\chromatin-dysregulation-cancer\\chromatin-dysregulation-cancer.review.md",
  "level_before": "Γ",
  "level_after": "Γ",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "confidence_band_rederived": true,
  "momentum_before": "Decisive work underway",
  "momentum_after": "Mechanistic only",
  "approval": "Approved as revised",
  "pmids_checked": 60,
  "pmids_failed": 0,
  "retractions_found": 0,
  "expressions_of_concern_verified": ["42760338"],
  "errata_verified": ["31558726", "36944736", "36697833", "36697834", "42138980"],
  "errata_claimed_but_nonexistent": ["20951942 (no identifier given; no correction record in PubMed)"],
  "claims_spot_checked": 11,
  "validator": {"tool": "validate_review.py", "version": "2.3", "ok": true, "FAIL": 0, "WARN": 1, "PASS": 30},
  "counts": {"critical": 0, "major": 3, "minor": 3, "editorial": 1},
  "findings": [
    {
      "id": "CD-1",
      "severity": "Major",
      "category": "momentum boilerplate without a named artifact",
      "location": "AT A GLANCE table; extended_scoring_MSD.momentum; Final score M/S/D",
      "original": "Decisive work underway. Named recent primary perturbation studies in this corpus test mechanistic or functional boundaries; no claim of a presently recruiting trial is made.",
      "corrected": "Mechanistic only, with the artifact rewritten to name the completed studies explicitly.",
      "evidence": "Artifact named no specific work and disclaimed a recruiting trial. Lead policy: a completed publication or trial never satisfies 'Decisive work underway'. Momentum modifies no letter."
    },
    {
      "id": "CD-2",
      "severity": "Major",
      "category": "confidence band justified by reviewer access depth",
      "location": "AT A GLANCE (new Confidence basis paragraph); final_score.confidence_rationale and two mirrored copies",
      "original": "60 primary reports with 8 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness.",
      "corrected": "Rationale grounded in evidence density and reproducibility, with reviewer access depth explicitly excluded.",
      "evidence": "Lead policy; hsef-framework.md section Confidence band. Two-step test applied; substantive evidence-quality concerns remain, so Moderate stands."
    },
    {
      "id": "CD-3",
      "severity": "Major",
      "category": "false provenance / spliced sentence",
      "location": "Consensus provenance reconciliation block",
      "original": "The earlier adversarial approval refers to its original edition; this provenance supplement is not a new independent or blinded adjudication.",
      "corrected": "No earlier adversarial approval exists for any edition of this review; this provenance supplement is not an independent or blinded adjudication.",
      "evidence": "No edition carries an approval section or line; the 2026-10-06 pass covered 30 other slugs."
    },
    {
      "id": "CD-4",
      "severity": "Minor",
      "category": "rendering defect (glued numerals)",
      "location": "47 sites across evidence narrative, perturbation inventory, falsification list, timeline, reviewer notes and evidence cards",
      "original": "earnsΕ, suppliesΔ, remainsΓ, in6/22, versus0/18, at18/20years, at29/31, chromosome12p, trisomy15, chromosome15, report26552009, Concern42760338, The2026, adjustments5.3%, section6, after60-80days, in7of16, Related28059768, summary28401192, correction42138980, around5percent, yields6/22, gain12p, with12p, Step1-Step5, not5.4, Consensus2Pro/0API/0Deep, cutoff2026-10-08, examinationsOct9UTC",
      "corrected": "spaces restored at all 47 sites (32 distinct patterns)",
      "evidence": "Known upstream renderer defect 4. Worst instances ran PMIDs into surrounding words at the Expression-of-Concern disclosure. Digit-bearing gene and allele names left untouched."
    },
    {
      "id": "CD-5",
      "severity": "Minor",
      "category": "rendering defect / unverifiable status flag",
      "location": "Evidence card [9] Access/status line (Wilson 2010, PMID 20951942)",
      "original": "ErratumIn: PMIDnot supplied.",
      "corrected": "Correction screen: no erratum, corrigendum or retraction record is indexed in PubMed for this report; status_checked_on 2026-10-14.",
      "evidence": "PubMed holds no correction record for PMID 20951942."
    },
    {
      "id": "CD-6",
      "severity": "Minor",
      "category": "rendering defect (empty DOI field)",
      "location": "REFERENCES entry 8 (Pantoja 2005)",
      "original": "DOI: .",
      "corrected": "DOI: none assigned (no DOI in the PubMed record).",
      "evidence": "PubMed holds no DOI for PMID 15665276."
    },
    {
      "id": "CD-E1",
      "severity": "Editorial",
      "category": "rendering",
      "location": "PROPOSED DECISIVE EXPERIMENTS",
      "original": "four doubled full stops",
      "corrected": "single full stops",
      "evidence": "Rendering."
    }
  ],
  "rejected_findings": [
    "Best-supported rival renderer defect - rank 1 is is_nominal false; nominal M1 ranks 5.",
    "Six print vs e-pub year differences of one - standing convention.",
    "Two title mismatches from PubMed field loss (Kras G12D superscript; DNMT3A R882) - standing convention.",
    "Bare-numeral citation form in prose - systematic house convention.",
    "v5.claim_form 'phenomenon' warning - standing convention.",
    "REVIEWER NOTES vs spliced Consensus section - no contradiction.",
    "Collective authors - screened in both forms (leading comma; consortium truncated to its last word) plus nobiliary particles. Reference 58 (PMID 32025007) is a genuine consortium record and renders with the full name ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. No defect.",
    "Scope-matched aggregation - checked closely; letter correctly taken from SC4, the only scope-matching subclaim, with the fly Ε and Δ results reported separately.",
    "Stability 'Stable' - correct by definition where no trigger is named."
  ],
  "residual_limitations": "Access depth unchanged (8 partial-body, 52 abstract/status). Expression-of-Concern body and six confirmed corrections unexamined in substance. Partial-body figures for Parreno, Cui, Yu, Gong and PCAWG section 6 not re-verifiable from abstracts; not contradicted.",
  "changed_files": [
    {"path": "chromatin-dysregulation-cancer.review.md", "sha256": "4d1590fa9892364f8f5eabdedd6b6c1e0e2e6d84264cbff8b8c6e865de008bc5", "bytes": 112256},
    {"path": "chromatin-dysregulation-cancer.scorecard.json", "sha256": "6605ffb4a59630a82e6817c4e39d312dd71ea2d87d4c4ac7f1c5e60b7972647c", "bytes": 280744},
    {"path": "SHA256.txt", "note": "regenerated"},
    {"path": "validation-report.json", "note": "re-run, ok=true"}
  ],
  "propagate_to": [],
  "divergent_copies_not_touched": [
    "hsef_v53_popularity_ranks_41_45_2026-10-08\\chromatin-dysregulation-cancer\\chromatin-dysregulation-cancer.review.md"
  ],
  "package_level_strings_for_lead": [
    {"old": "Decisive work underway", "new": "Mechanistic only", "scope": "chromatin-dysregulation-cancer M/S/D row only"}
  ],
  "consensus_questions": [
    "Outside Drosophila, has any study shown that a transient, fully reversed chromatin perturbation in a non-immortalised mammalian cell initiates a malignancy that whole-genome sequencing shows carries no cooperating driver lesion?"
  ]
}