{
  "completed": true,
  "status": "completed_original_source_reconciliation",
  "provider_mode": "Consensus Pro signed-in browser; observed output and citation link mappings",
  "queries": [
    "https://consensus.app/search/oral-creatine-cognitive-effects/S3fvy3sxRGutQPeOV2G4jw/"
  ],
  "query_record_note": "Exact visible question/response retained privately in raw browser receipt.",
  "primary_comparison_count": 9,
  "primary_comparisons": [
    {
      "pmid": "37968687",
      "doi": "10.1186/s12916-023-03146-5",
      "source_type": "primary study report",
      "study_group": "PMID37968687",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Consensus describes Sandkuhler2023 as a controlled trial with varied multiweek dosing and negligible/inconsistent effects through secondary review links.",
      "result_comparison": "Original Methods specifies one5g/day dose for sixweeks per phase in a preregistered123-person randomized crossover. Original Results distinguishes a small uncertain BDS effect from no clearRaven/exploratory benefit; it does not prove literally zero possible effect.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/37968687/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\examinations\\original-0-6-12000.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\37968687-s1-p0-3-4-5-20-25.json",
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\37968687-s2-p6-10-11-14-20-22-29.json"
      ]
    },
    {
      "pmid": "37968687",
      "doi": "10.1186/s12916-023-03146-5",
      "source_type": "primary study report",
      "study_group": "PMID37968687",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Consensus characterizes baseline dietary status as a major modifier and vegetarians as having intrinsically low tissuecreatine stores.",
      "result_comparison": "Original2023 Results directly tests the dietinteraction and finds no predicted difference; Rae2003 vegetarian recruitment does not supply an omnivore contrast or measured brain deficiency. Lower muscle stores cannot be assumed to mean lowerbrainstores.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/37968687/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\examinations\\original-0-6-12000.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\37968687-s1-p0-3-4-5-20-25.json",
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\37968687-s2-p6-10-11-14-20-22-29.json"
      ]
    },
    {
      "pmid": "38418482",
      "doi": "10.1038/s41598-024-54249-9",
      "source_type": "primary study report",
      "study_group": "GordjiNejad_highdose_sleep2024",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Consensus links the2024 cognitive andMRS changes but says elevated central phosphates cannot prove mediation.",
      "result_comparison": "OriginalMethods confirms a15-person randomized highdose sleep-loss crossover with spectroscopy/cognition and correlations. OriginalResults reports regionalcreatine/phosphate changes and performance shifts; no mediator perturbation occurs. Agreement on unproven mediation is retained, with multiple voxel/timepoint analysis limits stated.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/38418482/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\examinations\\original-13-20-12000.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\38418482-s1-p0-1-3-19-21.json",
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\38418482-s2-p18-20-22-24-25-27.json"
      ]
    },
    {
      "pmid": "40520504",
      "doi": "10.3389/fnins.2025.1515761",
      "source_type": "primary study report",
      "study_group": "GordjiNejad_highdose_sleep2024",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Consensus cites Gordji-Nejad2025 hemisphericATP balance alongside2024 cognitive effects.",
      "result_comparison": "Original2025 abstract identifies a new analysis of the previously published study. This is one15-person dataset with38418482, not independent replication or a second causal line.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/40520504/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\examinations\\original-20-26-12000.json"
      ],
      "body_receipts": []
    },
    {
      "pmid": "42075005",
      "doi": "10.3390/nu18081192",
      "source_type": "primary study report",
      "study_group": "PMID42075005",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Consensus says acute0.20–0.35g/kg protocols reverse sleep-loss deterioration in vigilance and verbal latency.",
      "result_comparison": "Original2026 selectedMethods uses a29-person crossover with participant-levelLMM plus pooled repeated-time contrasts. OriginalResults shows heterogeneous corrected outcomes and subgroup effects; a headline12percent or a single improved domain is not uniform reversal of impairment or a validated sex-specific dose rule.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/42075005/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\examinations\\original-6-13-12000.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\42075005-s1-p1-9-10.json",
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\42075005-s2-p8-9.json"
      ]
    },
    {
      "pmid": "40854087",
      "doi": "10.1080/27697061.2025.2551184",
      "source_type": "primary study report",
      "study_group": "PMID40854087",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Consensus was asked to include CONCRET-MENOPA but does not describe its original findings in the rendered milestone table.",
      "result_comparison": "Original2026 abstract reports36 women randomized to three hydrochloride/ethylester formulations orplacebo and selected reactiontime/frontalcreatine gains. It is retained as a small recent positive with multiplecomparisons and unavailablebody, rather than erased by a provider coverage gap or accepted as broadmenopausecognition proof.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/40854087/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\examinations\\original-0-6-12000.json"
      ],
      "body_receipts": []
    },
    {
      "pmid": "24098469",
      "doi": "10.1371/journal.pone.0076301",
      "source_type": "primary study report",
      "study_group": "PMID24098469",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Consensus broadly acknowledges null geriatric executive findings without detailing the24week olderwomen factorial trial.",
      "result_comparison": "OriginalMethods/Results confirm56 healthy olderwomen, codedcreatine/placebo with andwithouttraining, and no cognitive differences; training mood/strength benefit was not an additivecreatine cognitive effect.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/24098469/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\examinations\\original-6-13-12000.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\24098469-s1-p1-2-3-5-9.json",
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\24098469-s2-p3-7-9.json"
      ]
    },
    {
      "pmid": "37759877",
      "doi": "10.3390/brainsci13091276",
      "source_type": "primary study report",
      "study_group": "PMID37759877",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Consensus gap text says simultaneous pre/post brain spectroscopy and cognition in restedomnivores is absent.",
      "result_comparison": "The examined2023 trial pairs cognition withfNIRS, notMRS, and is null. Other records pairMRS/cognition inchildren andmenopause, while2023adulttrial has noMRS. This bounded set supports a need for wellpowered pairedstudies but cannot verify an absolute absence claim about every restedomnivoretrial; providergrid counts are not a systematic census.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/37759877/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\examinations\\original-6-13-12000.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\37759877-s1-p0-5-8.json",
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\body-presentation-receipts\\37759877-s2-p0-1.json"
      ]
    },
    {
      "pmid": "14561278",
      "doi": "10.1098/rspb.2003.2492",
      "source_type": "primary study report",
      "study_group": "PMID14561278",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Consensus correctly describes45 youngvegetarians,5g/day sixweeks and positiveworkingmemory/Raven scores, withnoMRSintr ial.",
      "result_comparison": "Originalabstract confirms the population/exposure/positive cognitive findings. Largeeffects remain a real result, but no samepersonbrainmeasurement establishes energeticmediation and subsequentlargertrial narrows expected magnitude.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/14561278/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\examinations\\original-25-32-12000.json"
      ],
      "body_receipts": []
    }
  ],
  "grade_changed": false,
  "grade_change_note": "Source-based adjudication; no independent blinded regrade claimed.",
  "raw_receipts": [
    {
      "path": "deliverables\\hsef_v53_traffic_first_five_2026-10-12\\creatine-cognition\\consensus-browser-2026-10-12.json",
      "sha256": "ce5ac9fba49655f1009c9236edd0f942ea1023551cbcd8546fba33b9625d91c8"
    }
  ],
  "independent_blinded_audit": false,
  "cutoff": "2026-10-12",
  "completed_utc": "2026-10-13T06:24:57.495602+00:00",
  "conclusion": "Endpoint hierarchy, experimental scope and original-source limits determine the evidence cards; provider wording does not override them."
}
