# Narration and storyboard draft: Creatine and Cognitive Performance

Authored draft, approximately 60–90 seconds; no rendered video claimed.

Creatine has strong reasons to interest brain researchers: it participates in cellular energy buffering, and oral exposure can change brain creatine. Those facts do not guarantee better memory in every healthy person. Controlled sleep-loss and oxygen-deprivation studies report protection on selected cognitive tasks. A large preregistered rested-adult study found only small uncertain benefits and did not confirm a vegetarian advantage. Other young-adult trials and a twenty-four-week older-women trial were null. New menopause studies are useful positive leads, but small groups and selected endpoints require replication. Our HSEF v5.3 primary cognitive claim reaches Ε, context-specific causality established, with Moderate confidence. Proposed mediation through brain energy buffering remains Γ because no examined healthy-adult trial isolated the mediator. Brain spectroscopy, muscle performance, congenital deficiency rescue and Alzheimer pilot findings answer different questions. The review examines61 original reports across cognitive trials and explicitly labeled mechanism and boundary studies; it is not61 efficacy trials. Consensus helped cross-check specific protocol, result and coverage assertions, but the grades come from original-source appraisal. A useful next experiment would prospectively compare rested and stressed adults, measure brain exposure, control practice and expectancy, and test a clinically interpretable cognitive outcome.

1. Show the exact claim, grade and confidence.
2. Show selected publication milestones; label experimental systems and clinical endpoints.
3. Contrast the strongest result with its source-specific limitation.
4. End with the boundary experiment and primary-source links.

Use authored schematics; do not depict Consensus meters as causal confidence or reproduce publisher graphics without appropriate permission.