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  "status": "completed_original_source_reconciliation",
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  "query_record_note": "Exact visible question/response retained privately in raw browser receipt.",
  "primary_comparison_count": 9,
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    {
      "pmid": "11083734",
      "doi": "10.1136/heart.84.6.595",
      "source_type": "primary study report",
      "study_group": "AMSTERDAM_FAMINE",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Consensus reproduces the Dutch early-gestation CAD odds ratio via a review.",
      "result_comparison": "The original clinical cohort reports the early-gestation association with a small exposed group and wide interval; mid/late groups are not increased. This is a valid natural-experiment lead with a mapped window, not uniform famine proof.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/11083734/",
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      "pmid": "22895645",
      "doi": "10.1136/heartjnl-2012-302419",
      "source_type": "primary study report",
      "study_group": "DUTCH_FAMILIES",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Consensus notes mixed geography but its synthesis does not show the independent Dutch CAD-null primary.",
      "result_comparison": "The original Dutch Families report includes time and sibling controls and finds no increased CAD or ECG risk. It is a distinct cohort contrast, retained alongside the positive Amsterdam series.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/22895645/",
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      "pmid": "11118027",
      "doi": "10.2337/diabetes.49.12.2208",
      "source_type": "primary study report",
      "study_group": "PMID11118027",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "The requested discordant maternal-diabetes sibling design is absent from the observed provider synthesis.",
      "result_comparison": "The original primary abstract reports higher offspring diabetes/BMI after maternal diagnosis, with paternal-diagnosis comparisons null. This strengthens restricted prenatal human causality beyond a birthweight association, while maternal age and birth order remain.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/11118027/",
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    {
      "pmid": "31043758",
      "doi": "10.1038/s41588-019-0403-1",
      "source_type": "primary study report",
      "study_group": "PMID31043758",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Consensus discusses genetics but omits the original maternal/fetal conditional birthweight-BP countercheck.",
      "result_comparison": "Original Results separates transmission from maternal intrauterine effects: maternal lower-birthweight genetic score does not raise adult offspring SBP after fetal adjustment. Its original GWAS/conditional analyses are examined; genetic birthweight cannot simply be renamed nutritional deprivation.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/31043758/",
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    {
      "pmid": "15924982",
      "doi": "10.1016/S0140-6736(05)66617-2",
      "source_type": "primary study report",
      "study_group": "PMID15924982",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "The observed synthesis lacks the randomized antenatal steroid adult follow-up.",
      "result_comparison": "The original thirty-year RCT follow-up finds no clinical CVD/diabetes or BP/lipid difference despite altered OGTT markers. Specific regimen, retention and horizon limits remain; a biomarker signal is not clinical disease programming.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/15924982/",
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      "pmid": "32692751",
      "doi": "10.1371/journal.pmed.1003183",
      "source_type": "primary study report",
      "study_group": "PMID32692751",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Provider recommends stronger prospective exposure trials; original intervention identity requires checking.",
      "result_comparison": "The original Methods defines the Hyderabad trial as nonrandomized, implemented by administrative block, with maternal supplementation and food through childhood. Adult risk-factor nulls cannot be represented as a prenatal-only randomized clinical trial.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/32692751/",
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    {
      "pmid": "39358993",
      "doi": "10.1093/aje/kwae376",
      "source_type": "primary study report",
      "study_group": "DUTCH_FAMILIES",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Consensus says negligible BMI polygenic-index differences demonstrate selection bias did not explain metabolic shifts.",
      "result_comparison": "The original updated primary reports no significant measured BMI-PGI difference. This constrains a specific genetic-selection mechanism, without excluding every non-genetic conception, survival or follow-up selection process. Its earlier preprint is not counted twice.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/39358993/",
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      "pmid": "39913677",
      "doi": "10.1093/eurjpc/zwaf059",
      "source_type": "primary study report",
      "study_group": "PMID39913677",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Consensus assigns cohort hazard ratios to a factorial Mendelian-randomization result and labels birthweight as nutrition.",
      "result_comparison": "Original abstract reports cohort Cox hazard ratios separately from factorial MR. The quoted5.16diabetes hazard ratio is observational. Birthweight genetics is not a direct prenatal nutrition instrument; HBW is at least2.5kg, not macrosomia. The issue-year2026 differs from the provider's2025dating, so date type must be stated.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/39913677/",
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      "pmid": "19386743",
      "doi": "10.3945/ajcn.2008.27038",
      "source_type": "primary study report",
      "study_group": "DUTCH_FAMILIES",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Consensus gives women-specific famine lipid differences relative to siblings.",
      "result_comparison": "Original study includes both time and sibling controls, finds women but not men affected, no gestational-window association and no HDL effect. These are lipid markers, not directly observed coronary events; triglycerides attenuate under adiposity adjustment.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/19386743/",
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  "grade_changed": false,
  "grade_change_note": "Source-based adjudication; no independent blinded regrade claimed.",
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  "independent_blinded_audit": false,
  "cutoff": "2026-10-09",
  "completed_utc": "2026-10-12T19:58:21.116708+00:00",
  "conclusion": "Endpoint hierarchy, experimental scope and original-source limits determine the evidence cards; provider wording does not override them."
}