# Consensus and original-source cross-check: Dopamine Hypothesis of Schizophrenia

Literature cutoff: 9 October 2026. Reconciliation completed 11 October 2026. Consensus Pro browser output is a discovery/synthesis aid; original source sections determine attribution. Provider meters are not evidence probabilities or examined-primary counts.

## Dopamine abnormalities precede some psychosis transitions.
Original prospective study body supports a striatal association in a small converter group. The limbic comparison is nonsignificant; a prospective association is not a selective mesolimbic necessity test. [Original primary source: PMID 21768612](https://pubmed.ncbi.nlm.nih.gov/21768612/). DOI: 10.1176/appi.ajp.2011.11010160. Access: full_text_partial.

## Treatment resistance can distinguish dopamine-related illness.
Original multicentre STRATA body finds no responder/nonresponder dopamine difference. A settled diagnostic classifier cannot be inferred from earlier small studies. [Original primary source: PMID 32910150](https://pubmed.ncbi.nlm.nih.gov/32910150/). DOI: 10.1093/schbul/sbaa128. Access: full_text_partial.

## Muscarinic treatment can improve psychotic symptoms.
Original EMERGENT-3 body verifies registration and a positive PANSS endpoint, but excludes treatment-resistant history and does not measure a selective dopamine mediator. It does not establish efficacy in TRS or dopamine dispensability. [Original primary source: PMID 38691387](https://pubmed.ncbi.nlm.nih.gov/38691387/). DOI: 10.1001/jamapsychiatry.2024.0785. Access: full_text_partial.

## D2 occupancy supports a symptom-treatment relationship.
Original primary abstract links occupancy to clinical response and adverse effects. This bounded audit does not verify a preregistered selective mesolimbic mediator/trajectory experiment; failure to verify that provenance is not failure of antipsychotic efficacy. [Original primary source: PMID 10739409](https://pubmed.ncbi.nlm.nih.gov/10739409/). DOI: 10.1176/appi.ajp.157.4.514. Access: abstract_metadata.

## Methods wording
Consensus was used to identify literature and cross-check specific claims about study design, endpoints, scope and research gaps. Those claims were checked against original primary abstracts/status records and, for selected studies, original Methods or Results passages. Consensus output was not treated as original full text. Source-specific access depth and receipts are retained. Scite supplied one five-anchor citation-context/tally query; returned contexts were outgoing references, not an audited incoming contradiction set. SciSpace supplied one discovery pass; it added no primary-count credit.