{
  "slug": "dopamine-schizophrenia",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "review_date": "2026-10-14",
  "round": 2,
  "group": 3,
  "level_before": "Γ",
  "level_after": "Γ",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "counts": { "critical": 0, "major": 1, "minor": 1, "editorial": 0 },
  "pmids_checked": 50,
  "pmids_failed": 0,
  "retractions_or_eoc_found": 0,
  "claims_spot_checked": 11,
  "validator": { "tool": "validate_review.py", "version": "2.3", "result": "PASS", "fail": 0, "warn": 0, "pass": 31, "output_file": "validator.txt" },
  "findings": [
    {
      "id": "DS-1",
      "severity": "Major",
      "action": "recorded; no level changed",
      "type": "calibration_evidence_identification_gap",
      "location": "SC2 subclaim level; causal tally",
      "original": "SC2 = Γ; tally '0 positive qualifying study units'",
      "corrected": "retained, with the limitation recorded in the review's ADVERSARIAL REVIEW AND APPROVAL section and referred to the editorial lead",
      "evidence": "Rubric 07 lists 'blinding-integrity-reported randomized trials, discontinuation and rechallenge designs, and genetic instruments' as field-valid equivalents and states they exist so a convergent case is 'not capped by the absence of a clean blind'. The examined body contains a single-blind dose-reduction pilot (PMID31188232) and an AMPT depletion study with subjective-effect outcomes (PMID11682247) but no registered blinded randomized-withdrawal trial, though that design class exists in the literature. The headline is set by SC3 under the preregistered primary-subclaim rule and would remain Γ either way.",
      "recommended_action": "Commission a targeted retrieval of registered discontinuation / randomized-withdrawal antipsychotic trials and re-score SC2 before publication."
    },
    {
      "id": "DS-2",
      "severity": "Minor",
      "type": "false_provenance_boilerplate",
      "location": "Registered claim and scope, Selection line",
      "original": "Registered claim assessed against original sources; existing HIV draft consulted after a source-based checkpoint. This is not independent blinded calibration.",
      "corrected": "Registered claim assessed against original sources. This is not independent blinded calibration.",
      "evidence": "Batch boilerplate present in all five cases of hsef_v53_remaining_priority_06_10_2026-10-09; accurate only for hiv-aids."
    }
  ],
  "rejected_findings": [
    "Headline Γ for SC3 — registered claim fixes mesolimbic anatomy and unselected primacy; strongest human findings are associative-striatal and STRATA finds no responder/non-responder striatal dopamine difference. Neither Δ nor Β is forced.",
    "Confidence Moderate — matches the band's 'methodological heterogeneity' clause.",
    "Momentum 'Mechanistic only' names its artifacts (PMID39632880; EMERGENT-3 NCT04738123).",
    "Divergence 'Contested' — field genuinely split.",
    "Primary-subclaim aggregation on SC3 returns Γ; alternatives reported (weakest-link Β, scope-matched Γ).",
    "upper_ladder_check records the equivalents considered and why none carried the claim further, as rubric 07 requires below Ζ.",
    "Numeric and design claims verified: PMIDs 21768612, 20194823, 23034655, 32910150, 38691387, 31188232, 39632880, 10739409, 11682247.",
    "PubMed dropping subscripts in 'D2/3' (reference 23) — PubMed artifact."
  ],
  "residual_limitations": [
    "Access depth unchanged: 3 partial-body and 47 abstract/status examinations.",
    "Registration and expectancy provenance for historical challenge and occupancy studies not recovered (basis of the conservative SC2 gate; see DS-1)."
  ],
  "propagation": {
    "old_new_strings": [
      ["Registered claim assessed against original sources; existing HIV draft consulted after a source-based checkpoint.", "Registered claim assessed against original sources."]
    ],
    "note": "No level or confidence change. MANIFEST/PACKAGE_SHA256/BATCH_COMPLETION hash entries for dopamine-schizophrenia.review.md need refreshing (new hash in SHA256.txt); the scorecard is unchanged."
  },
  "status": "Approved as revised"
}