{
  "completed": true,
  "status": "completed_original_source_reconciliation",
  "provider_mode": "Consensus Pro signed-in browser; observed output and citation link mappings",
  "queries": [
    "https://consensus.app/search/enhancer-promoter-contact-transcription/OQMFd7VjTmK_DECg-Vyuqw/"
  ],
  "query_record_note": "Exact visible question/response retained privately in raw browser receipt.",
  "primary_comparison_count": 8,
  "primary_comparisons": [
    {
      "pmid": "22682246",
      "doi": "10.1016/j.cell.2012.03.051",
      "source_type": "primary study report",
      "study_group": "PMID22682246",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Engineered functional sufficiency, not natural continuous necessity",
      "result_comparison": "The original native-globin experiment supports activation by an active LDB1 tether with enhancer-dependent allele controls. Consensus correctly identifies a functional forced-looping result. The target gene is endogenous, but the recruited protein construct is synthetic; this does not prove geometry alone sufficient or contact continuously necessary.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/22682246/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\enhancer-promoter-looping\\examinations\\original-20-40-6500.json"
      ],
      "body_receipts": [
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      ]
    },
    {
      "pmid": "27067601",
      "doi": "10.1016/j.molcel.2016.03.007",
      "source_type": "primary study report",
      "study_group": "PMID27067601",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Burst fraction differs from live burst frequency",
      "result_comparison": "The original Results confirm increased snapshot burst fraction without increased burst size after forced contacts. The paper explicitly reserves definitive competing-contact dynamics for direct live imaging. Consensus's frequency language must therefore distinguish inferred likelihood from measured initiation frequency.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/27067601/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\enhancer-promoter-looping\\examinations\\original-40-60-6500.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\enhancer-promoter-looping\\body-presentation-receipts\\27067601-s1-p7-8-11-18.json"
      ]
    },
    {
      "pmid": "31124784",
      "doi": "10.7554/eLife.41769",
      "source_type": "primary study report",
      "study_group": "PMID31124784",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Sox2 spatial decoupling within measured resolution",
      "result_comparison": "The original same-cell imaging finds no contemporaneous or tested lag-window proximity relation to enhancer-dependent bursts. Original labels are offset by kilobases, and reporter delays and finite resolution leave brief or earlier contacts possible. The provider's initial categorical no-contact wording is too broad; its later targeted answer recognizes this limitation. Canonical original publication is 2019, despite provider 2018 labels.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/31124784/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\enhancer-promoter-looping\\examinations\\original-0-20-6500.json"
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      ]
    },
    {
      "pmid": "31494034",
      "doi": "10.1016/j.molcel.2019.07.038",
      "source_type": "primary study report",
      "study_group": "PMID31494034",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Neural Shh enhancers are not the limb ZRS",
      "result_comparison": "The original Results examine brain enhancers during neural differentiation and embryonic neural tissue. Activation increases measured separation, with a synthetic-loop positive imaging control. Consensus initially mislabels this as a limb-enhancer finding and cannot retrieve the exact paper in its targeted answer. The original body corrects the anatomy and preserves the fixed-assay limitation.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/31494034/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\enhancer-promoter-looping\\examinations\\original-20-40-6500.json"
      ],
      "body_receipts": [
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      ]
    },
    {
      "pmid": "36471071",
      "doi": "10.1038/s41588-022-01223-8",
      "source_type": "primary study report",
      "study_group": "PMID36471071",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Architectural loss retains most enhancer contacts",
      "result_comparison": "The original Results show approximately 80% of enhancer-promoter contacts remain unaltered after acute CTCF/cohesin depletion, while short-term gene changes are modest. This is an extrusion-factor maintenance test, not selective elimination of every productive contact. The targeted provider correctly cautions about retained contacts but did not validate this exact paper itself.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/36471071/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\enhancer-promoter-looping\\examinations\\original-0-20-6500.json"
      ],
      "body_receipts": [
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      ]
    },
    {
      "pmid": "24874989",
      "doi": "10.1101/gad.239749.114",
      "source_type": "primary study report",
      "study_group": "PMID24874989",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Correct original year and loop-competent mutant",
      "result_comparison": "The original 2014 paper restores globin looping with LDB1 DD4/5 deletion without restoring transcription or polymerase recruitment. Consensus's exact-paper search failed and relied on 2013-labeled title surrogates. The original result separates looping from downstream activation chemistry; it does not prove all contacts unnecessary.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/24874989/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\enhancer-promoter-looping\\examinations\\original-20-40-6500.json"
      ],
      "body_receipts": [
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      ]
    },
    {
      "pmid": "35418676",
      "doi": "10.1038/s41586-022-04570-y",
      "source_type": "primary study report",
      "study_group": "PMID35418676",
      "access_depth": "full_text_partial",
      "consensus_aspect": "The 2022 graded landscape is a distinct publication",
      "result_comparison": "The original 2022 study uses an ectopic regulatory landscape and largely founder-line contact probabilities to fit nonlinear promoter on-rate behavior. It is distinct from the 2026 live burst-cluster paper. Consensus's conditional conflation of the papers is corrected; neither proves universal continuous native-locus contact necessity.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/35418676/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\enhancer-promoter-looping\\examinations\\original-0-20-6500.json"
      ],
      "body_receipts": [
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      ]
    },
    {
      "pmid": "35896525",
      "doi": "10.1038/s41467-022-31192-9",
      "source_type": "primary study report",
      "study_group": "PMID35896525",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Conditional macrophage deletion is not acute degradation",
      "result_comparison": "The original Methods/Results use conditional Rad21 deletion in quiescent macrophages, with cell-cycle and damage checks. Burst participation is uncoupled despite similar measured enhancer-promoter distances at several loci. Consensus called this acute degradation; the original experiment corrects the intervention identity and retains resolution limitations.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/35896525/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\enhancer-promoter-looping\\examinations\\original-0-20-6500.json"
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      "body_receipts": [
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      ]
    }
  ],
  "grade_changed": false,
  "grade_change_note": "Source-based adjudication; no independent blinded regrade claimed.",
  "raw_receipts": [
    {
      "path": "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\enhancer-promoter-looping\\consensus-browser-2026-10-12.json",
      "sha256": "d0bd3fe67d4150f6d2cdf21c99a04451d929b9093434d441cebd6f66471aebfc"
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  "independent_blinded_audit": false,
  "cutoff": "2026-10-09",
  "completed_utc": "2026-10-12T19:55:27.278692+00:00",
  "conclusion": "Endpoint hierarchy, experimental scope and original-source limits determine the evidence cards; provider wording does not override them."
}