{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used bounded original primary abstract passages/status records and selected original partial-body passages. No complete-abstract or complete-paper audit, or independent scientific peer review, is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "Enhancers regulate genes, but continuous physical contact throughout every transcriptional burst is contradicted by native-locus measurements within their detection limits.",
  "implications": "The registered primary SC3 necessity gate is Β: partial mechanistic plausibility is capped at Γ, then one endogenous-prediction falsification pattern lowers it one rung. Native Sox2 simultaneous imaging and orthogonal neural Shh/estrogen distance findings oppose the universal sustained-contact prediction within detection limits. This is neither proof that brief contacts never occur nor a denial of causal enhancer function. Exact index additionally restricts synthetic SC2 sufficiency to Γ; broad SC4 graded frequency remains Γ because its strongest controlled tests use synthetic tethers/landscapes and snapshot or inferred kinetics.",
  "limitations": "57 primary reports with 10 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}