{
  "completed": true,
  "status": "documented_historical_discovery_and_reconciliation",
  "provider": "Consensus",
  "provider_mode": "Historical browser/connector use as recorded in the source artifacts",
  "local_audit_date": "2026-10-09",
  "primary_comparison_count": null,
  "reported_usage": [],
  "grade_changed": false,
  "score_before": {
    "hsef_level": "Γ",
    "hsef_descriptor": "Mechanistically plausible, partial system support",
    "confidence": "Low",
    "confidence_rationale": "Confidence measures evidence density and reproducibility, not the reviewer's certainty about the verdict. Every criterion of the framework's Low band is met: the literature is small; eleven of the twelve sources in the prior edition originate in one connected research network and its declared collaborators, the sole exception being the 2025 independent cell-line study; no organism-level result has been reproduced outside that network; two rodent survival reports are available only as English abstracts; two primaries are image-only scans; and the single independent human-cell study required replacement of all three core data figures. The prior edition assigned High on the ground that confidence in the location of the ceiling was high, which is the reading the framework explicitly rules out. The level itself is stable, and that is a separate axis.",
    "rests_on_non_peer_reviewed_work": false,
    "rationale": "Cultured-cell findings in three laboratories make telomerase activation mechanistically plausible. The claim cannot cross Δ because no intervention with this peptide demonstrates telomerase activation in living humans, durable human telomere maintenance, or extension of validated human healthspan, and no study in any system establishes telomerase mediation. At the claimed human scope there is no evidence at all; the level is carried by cell-culture and animal systems, which is what Γ describes."
  },
  "score_after": {
    "hsef_level": "Γ",
    "hsef_descriptor": "Mechanistically plausible, partial system support",
    "confidence": "Low",
    "confidence_rationale": "Confidence measures evidence density and reproducibility, not the reviewer's certainty about the verdict. Every criterion of the framework's Low band is met: the literature is small; eleven of the twelve sources in the prior edition originate in one connected research network and its declared collaborators, the sole exception being the 2025 independent cell-line study; no organism-level result has been reproduced outside that network; two rodent survival reports are available only as English abstracts; two primaries are image-only scans; and the single independent human-cell study required replacement of all three core data figures. The prior edition assigned High on the ground that confidence in the location of the ceiling was high, which is the reading the framework explicitly rules out. The level itself is stable, and that is a separate axis.",
    "rests_on_non_peer_reviewed_work": false,
    "rationale": "Cultured-cell findings in three laboratories make telomerase activation mechanistically plausible. The claim cannot cross Δ because no intervention with this peptide demonstrates telomerase activation in living humans, durable human telomere maintenance, or extension of validated human healthspan, and no study in any system establishes telomerase mediation. At the claimed human scope there is no evidence at all; the level is carried by cell-culture and animal systems, which is what Γ describes."
  },
  "independent_blinded_audit": false,
  "raw_receipts": [
    {
      "path": "deliverables\\prepublication-enrichment-2026-10-05\\website-series\\epitalon-telomerase\\consensus-browser-links.json",
      "sha256": "83c96e2919e70860e09a5ffb90af5d98b0f2daa6bb8b8b09e3f0cec095226f82"
    },
    {
      "path": "deliverables\\prepublication-enrichment-2026-10-05\\website-series\\epitalon-telomerase\\consensus-browser.txt",
      "sha256": "daa27357fde4f5d327c518edc3caab8102e200550387e3853a3d5ca1a102ff88"
    },
    {
      "path": "deliverables\\prepublication-enrichment-2026-10-05\\website-series\\epitalon-telomerase\\consensus-targeted-check.txt",
      "sha256": "27fe8179d2490051692715f6b29fefaf5046fbe79488fe2b4e6465674de8f757"
    }
  ],
  "limitations": "This verifies documented historical use and links the record to the final edition. It adds no primary-source, full-text, independence or verification credit. Original access remains limited to the source-specific record.",
  "existing_primary_reconciliation": {
    "slug": "epitalon-telomerase",
    "consensus_used": true,
    "rawproof": [
      "deliverables/prepublication-enrichment-2026-10-05/website-series/epitalon-telomerase/consensus-browser.txt",
      "deliverables/prepublication-enrichment-2026-10-05/website-series/epitalon-telomerase/consensus-targeted-check.txt",
      "deliverables/prepublication-enrichment-2026-10-05/website-series/epitalon-telomerase/consensus-browser-links.json"
    ],
    "reconciliation_existing": "Yes; 8 identifiers; selected Methods/Results passage and correction PMID 41240216 noted; corrected figures not re-quantified.",
    "primary_sources_matched": [
      "11087911",
      "12937682",
      "14501183",
      "14523363",
      "15455129",
      "28241208",
      "40493162",
      "40908429"
    ],
    "limitations": "Targeted paper check covers specified cell lines/results only; correction means image-based quantitative claims need corrected-figure appraisal."
  }
}