{
  "slug": "excitotoxicity-als",
  "edition": "revised (consensus_consistency_audit_2026-10-09)",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "review_date": "2026-10-14",
  "round": 2,
  "group": 3,
  "level_before": "Γ",
  "level_after": "Γ",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "momentum_before": "Decisive work underway",
  "momentum_after": "Mechanistic only",
  "counts": {
    "critical": 0,
    "major": 1,
    "minor": 3,
    "editorial": 0
  },
  "pmids_checked": 69,
  "pmids_failed": 0,
  "retractions_or_eoc_found": 0,
  "claims_spot_checked": 12,
  "validator": {
    "tool": "validate_review.py",
    "version": "2.3",
    "sha256": "e91528f691a3600c9daf131433b48a56b73b2407ec08df8fbf5318f8500981ad",
    "result": "PASS",
    "fail": 0,
    "warn": 1,
    "pass": 30,
    "warn_detail": "v5.claim_form entry_form 'phenomenon' — identical to pre-review baseline; standing rejected convention",
    "output_file": "validator.txt"
  },
  "findings": [
    {
      "id": "EX-1",
      "severity": "Major",
      "type": "momentum_boilerplate",
      "location": "AT A GLANCE table; 'Momentum:' line; score card extended_scoring_MSD.momentum",
      "original": "Decisive work underway — 'Named recent primary perturbation studies in this corpus test mechanistic or functional boundaries; no claim of a presently recruiting trial is made.'",
      "corrected": "Mechanistic only — artifact now names RIPK1 glial-state perturbation (PMID40132594), astrocytic YAP/EAAT2 rescue (PMID40860154) and targeted STMN2 processing correction (PMID36927019), and states that no programme addresses the sporadic-human dependency boundary check.",
      "evidence": "Framework Momentum table plus the required-artifact rule; the original artifact named no work and disclaimed a recruiting trial, and the review's decisive-experiment section says the boundary test does not exist. Momentum modifies no letter."
    },
    {
      "id": "EX-2",
      "severity": "Minor",
      "type": "misstatement_regression",
      "location": "Consensus provenance reconciliation block; consensus-addendum.md",
      "original": "The earlier adversarial approval refers to its original edition; ...",
      "corrected": "No earlier adversarial approval is attached to this case; ...",
      "evidence": "Neither edition contains an adversarial section or log; the sentence is unconditional boilerplate in integrate_consensus.py. Introduced by the revision, so a regression."
    },
    {
      "id": "EX-3",
      "severity": "Minor",
      "type": "rendering_defect",
      "location": "Falsification and pitfalls",
      "original": "PMID24094105 and32484501",
      "corrected": "PMID24094105 and 32484501",
      "evidence": "Missing space before numeral."
    },
    {
      "id": "EX-4",
      "severity": "Minor",
      "type": "rendering_defect",
      "location": "REFERENCES entry 11",
      "original": "DOI: .",
      "corrected": "No DOI in the PubMed record.",
      "evidence": "Empty DOI field; PubMed record for PMID 11357955 carries no DOI."
    }
  ],
  "rejected_findings": [
    "SC2 at Ζ — independence_basis present with four named lines and their distinct excluded errors; scope is forced-lesion sufficiency; does not gate the headline.",
    "Scope-matched aggregation correctly returns SC4 (Γ); narrower Ζ/Ε subclaims reported separately; both alternative rules reported.",
    "Validator WARN v5.claim_form 'phenomenon' — claim states mechanism plus consequence (standing convention).",
    "Reference 16 year 2022 vs PubMed 2021 — ±1 print/e-pub.",
    "PubMed title fields dropping italicised gene names (reference 49, STMN2).",
    "Headline Γ re-derived against the Β/Γ/Δ boundary; neither Δ nor Β is forced.",
    "Numeric claims verified against abstracts/trial records: PMIDs 25297012, 34191081, 8302340, 8676624, 19961264, 33226425, 28342750, 29458024.",
    "Lead-reported batch-wide revision artifact (spliced Consensus block beside preserved REVIEWER NOTES denying Consensus work) — checked and not present in this case; preserved notes affirm browser use and only deny API calls. review_metadata.reviewer 'Codex' left unedited as house provenance."
  ],
  "residual_limitations": [
    "Spinal GLT1 lesion (PMID 29458024) remains abstract-only; its controls are unaudited.",
    "Linked errata PMID 38890465 and PMID 36480942 recorded but unexamined.",
    "Access depth unchanged: 6 partial-body and 63 abstract/status examinations."
  ],
  "divergent_copies_not_edited": [
    "hsef_v53_popularity_ranks_31_35_2026-10-08\\excitotoxicity-als\\excitotoxicity-als.review.md (still carries EX-1, EX-3, EX-4; EX-2 absent there)"
  ],
  "propagation": {
    "old_new_strings": [
      [
        "| Γ — Mechanistically plausible, partial system support | Moderate | reinforcing / stabilizing factor | Decisive work underway | Stable | Contested |",
        "| Γ — Mechanistically plausible, partial system support | Moderate | reinforcing / stabilizing factor | Mechanistic only | Stable | Contested |"
      ],
      [
        "Momentum: Decisive work underway. Named recent primary perturbation studies in this corpus test mechanistic or functional boundaries; no claim of a presently recruiting trial is made.",
        "Momentum: Mechanistic only. Recent primary perturbation work in this corpus — RIPK1 glial-state perturbation (PMID40132594), astrocytic YAP/EAAT2 rescue in the poly-GA model (PMID40860154) and targeted STMN2 processing correction (PMID36927019) — tests mechanistic and functional boundaries. No trial or programme addressing the sporadic-human dependency boundary check is named, and no presently recruiting trial is claimed."
      ],
      [
        "PMID24094105 and32484501",
        "PMID24094105 and 32484501"
      ],
      [
        "DOI: . Access:",
        "No DOI in the PubMed record. Access:"
      ],
      [
        "The earlier adversarial approval refers to its original edition;",
        "No earlier adversarial approval is attached to this case;"
      ]
    ],
    "note": "Package-level files were not edited. Momentum appears in package OVERVIEW/READER artifacts where present and must be propagated by the lead."
  },
  "status": "Approved as revised"
}