{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "ALS damages the nerve cells that control muscles. This review asks whether excessive glutamate signaling drives that loss, separating engineered lesions, disease models and evidence from patients.",
  "implications": "Preregistered scope-matched SC4 returns Γ. SC2 Ζ is a bounded forced-lesion result, and SC3 Ε is a SOD1 progression result. Weakest-link sensitivity is Β from descriptive SC1, so that aggregation would mix association depth with a distinct causal-driver question.",
  "limitations": "69 primary reports with 6 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}