{
  "slug": "genome-instability-cancer",
  "edition": "consensus_consistency_audit_2026-10-09 revised",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "review_date": "2026-10-14",
  "round": 2,
  "level_before": "Γ",
  "level_after": "Γ",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "momentum_before": "Decisive work underway",
  "momentum_after": "Mechanistic only",
  "pmids_checked": 64,
  "pmids_failed": 0,
  "claims_spot_checked": 14,
  "claims_failed": 0,
  "findings_by_severity": {
    "Critical": 0,
    "Major": 2,
    "Minor": 4,
    "Editorial": 0
  },
  "findings": [
    {
      "id": "AR-1",
      "severity": "Major",
      "regression": true,
      "type": "false_provenance",
      "location": "spliced Consensus provenance reconciliation block; consensus-addendum.md",
      "original": "The earlier adversarial approval refers to its original edition; this provenance supplement is not a new independent or blinded adjudication.",
      "corrected": "No earlier adversarial approval is attached to this case; this provenance supplement is not a new independent or blinded adjudication, and nothing earlier certifies it.",
      "evidence": "The original edition at hsef_v53_popularity_ranks_36_40_2026-10-08/genome-instability-cancer/ carries no adversarial approval, and no approval statement appears anywhere in that batch."
    },
    {
      "id": "AR-2",
      "severity": "Major",
      "regression": false,
      "type": "momentum_boilerplate",
      "location": "AT A GLANCE table; M/S/D section; scorecard extended_scoring_MSD.momentum",
      "original": "Decisive work underway",
      "corrected": "Mechanistic only",
      "evidence": "Framework: 'Decisive work underway | Someone is running an experiment that could cross the next threshold.' The artifact names two completed 2025 publications (PMID 40670783, 41162705) already in the review's examined inventory, neither addressing the general-primacy boundary check; the Stability entry in the same block states no pending result was identified. Momentum modifies no letter."
    },
    {
      "id": "AR-3",
      "severity": "Minor",
      "regression": false,
      "type": "rendering",
      "location": "throughout",
      "original": "(PMID24133140,28132847,26578792,34266887); [PMID10608877](...); '11 of24'",
      "corrected": "(PMID 24133140, 28132847, 26578792, 34266887); [PMID 10608877](...); '11 of 24' (63 instances)",
      "evidence": "Known upstream rendering defect; whitespace only. Study: PMID... identifier tokens deliberately left unchanged."
    },
    {
      "id": "AR-4",
      "severity": "Minor",
      "regression": false,
      "type": "citation_rendering",
      "location": "REFERENCES 36, 52, 54, 56",
      "original": "DOI: .",
      "corrected": "No DOI in PubMed record.",
      "evidence": "PubMed XML for PMID 11861370, 8674041, 9973196, 8706033 carries no DOI ArticleId."
    },
    {
      "id": "AR-5",
      "severity": "Minor",
      "regression": false,
      "type": "status_flags",
      "location": "evidence cards for PMID 33361815, 30675059, 37410869",
      "original": "ErratumIn: PMID33649505. / ErratumIn: PMID42321512. / UpdateOf: PMID36711674.",
      "corrected": "Erratum in: Nature. 2021 Mar;591(7850):E19 (PMID 33649505). / Erratum in: Nature. 2026 Jul;655(8122):E3 (PMID 42321512). / Update of: bioRxiv. 2023 Jan 10:2023.01.09.523344 (PMID 36711674).",
      "evidence": "Citations read off each parent record's CommentsCorrections element; the ledger rule requires the correction's identifier to travel in the flag text."
    },
    {
      "id": "AR-6",
      "severity": "Minor",
      "regression": false,
      "type": "scoring_text",
      "location": "scorecard final_score.confidence_rationale (3 occurrences)",
      "original": "density, heterogeneous controls and incomplete access set the confidence, not correctness.",
      "corrected": "evidence density, heterogeneous controls and the predominance of engineered and transplant models set the confidence, not correctness and not reviewer access depth.",
      "evidence": "Lead two-step confidence policy 2026-10-14. Step 1 strikes access depth; step 2 leaves the band at Moderate because the review documents substantive evidence-quality reservations of its own."
    }
  ],
  "rejected_findings": [
    "Headline Gamma argued up to Epsilon/Zeta: rejected; primary-subclaim pre-registered on SC4 and both printed sensitivities are correct.",
    "Scope-matched arithmetic: correct. SC4 is the only scope-matching subclaim; SC2 is lesion/genotype-restricted and SC3 is an Epsilon and therefore scope-restricted by definition.",
    "SC2 at Zeta: independence basis recorded; survives the v5.2 shared-failure test.",
    "Causal role 'reinforcing / stabilizing factor': re-derived through the framework's ordered steps to the same answer.",
    "Best-supported rival renderer defect: does not fire; models_evaluated[0] is rank 1, is_nominal false, nominal is rank 5.",
    "Divergence 'Contested' with a recorded null implied level and stated basis: permitted.",
    "v5.claim_form validator warnings (both): rejected per round-2 convention; the restatement is a single well-formed causal claim and its 'or' sits in the contrast clause.",
    "Collective authors: TRACERx consortium absorbed into 'et al.'; no stray leading comma anywhere.",
    "Print/e-pub year plus-or-minus 1 differences and PubMed title-case normalisation: rejected per convention."
  ],
  "residual_limitations": [
    "53 of 61 records examined at complete-abstract/status depth.",
    "Two linked correction details remain unexamined in substance; this reviewer resolved their citations but did not read their content.",
    "provenance_header.generated_by reads 'Codex; HSEF v5.3' rather than naming Sol 6.1 (package-wide field, left for the lead)."
  ],
  "validator": {
    "result": "FAIL",
    "fails": 1,
    "warns": 2,
    "passes": 33,
    "detail": "v5.lay_summary (v5.4 rule against a v5.3 review, cross-version artifact) plus two v5.claim_form warnings rejected per round-2 convention.",
    "pre_review_validator": "none present in the revised case folder"
  },
  "files_changed": [
    "genome-instability-cancer.review.md",
    "genome-instability-cancer.scorecard.json",
    "consensus-addendum.md",
    "validator.txt"
  ],
  "divergent_copies_not_touched": [
    "hsef_v53_popularity_ranks_36_40_2026-10-08/genome-instability-cancer/genome-instability-cancer.review.md"
  ],
  "consensus_questions": [
    "Is there direct evidence in sporadic human cancers that an elevated chromosome-missegregation or mutation rate precedes, rather than follows, the first transforming driver event?"
  ]
}