{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "Cancer genomes can change during growth. This review asks when continuing mutation or chromosome errors initiate cancer, accelerate existing disease or restrain it, and whether those errors are the general root cause.",
  "implications": "The preregistered general-root gate SC4 remains Γ. Endogenous repair and segregation perturbations establish defined cancer-susceptibility routes (SC2 Ζ), and rate-specific progression or resistance interventions support context-valid causality (SC3 Ε). Associations and fixed abnormal states cannot establish the temporal root of all cancer.",
  "limitations": "61 primary reports with 8 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}