{
  "completed": true,
  "status": "completed_original_source_reconciliation",
  "provider_mode": "Consensus Pro signed-in browser; observed output and citation link mappings",
  "queries": [
    "https://consensus.app/search/sleep-dependent-glymphatic-clearance/vxKeWPICRkOBiMRfrm7_YQ/"
  ],
  "query_record_note": "Exact visible question/response retained privately in raw browser receipt.",
  "primary_comparison_count": 5,
  "primary_comparisons": [
    {
      "pmid": "38741022",
      "doi": "10.1038/s41593-024-01638-y",
      "source_type": "primary study report",
      "study_group": "PMID38741022",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Contrary sleep experiment omitted from the provider search",
      "result_comparison": "Consensus did not retrieve Miao's original study. Its examined original Results show lower small-dye net clearance during sleep or anesthesia with unchanged diffusion coefficients. This is contrary evidence for a uniform sleep-clearance prediction, with male-mouse, solute-size and preparation limits. The publisher correction repairs one source-data column; amended raw data have not been reanalyzed.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/38741022/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\glymphatic-clearance\\examinations\\original-0-10-2400.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\glymphatic-clearance\\body-presentation-receipts\\38741022-s0-p8-12-16-17.json"
      ]
    },
    {
      "pmid": "39788123",
      "doi": "10.1016/j.cell.2024.11.027",
      "source_type": "primary study report",
      "study_group": "PMID39788123",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Original experiment versus a similarly titled review",
      "result_comparison": "Consensus selected a 2025 review rather than the original Cell experiment. The original body separates an efflux assay from influx, finds associations with noradrenergic microarchitecture rather than total NREM duration, and reports zolpidem-reduced tracer influx. It does not establish that zolpidem causes human dementia.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/39788123/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\glymphatic-clearance\\examinations\\original-0-10-2400.json"
      ],
      "body_receipts": [
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      ]
    },
    {
      "pmid": "41593094",
      "doi": "10.1038/s41467-026-68374-8",
      "source_type": "primary study report",
      "study_group": "PMID41593094",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Human device modeling versus observed endogenous clearance",
      "result_comparison": "The original 2026 body reports no significant overall between-condition difference in overnight plasma biomarker changes, despite modeled physiological associations. Its abstract and measured-biomarker Results use different participant counts. An impedance/compartment estimate is not direct observation of net parenchymal export or a dementia-prevention outcome.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/41593094/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\glymphatic-clearance\\examinations\\original-10-30-1400.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\glymphatic-clearance\\body-presentation-receipts\\41593094-s1-p9.json",
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\glymphatic-clearance\\body-presentation-receipts\\41593094-s2-p0-1-18.json"
      ]
    },
    {
      "pmid": "29220873",
      "doi": "10.1002/ana.25117",
      "source_type": "primary study report",
      "study_group": "PMID29220873",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Production and clearance must be separated",
      "result_comparison": "Original human isotope kinetics attributes a deprivation-related amyloid increase to increased production, while fractional turnover and delay comparisons are nonsignificant. A concentration rise alone cannot validate reduced glymphatic clearance.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/29220873/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\glymphatic-clearance\\examinations\\original-0-10-2400.json"
      ],
      "body_receipts": [
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      ]
    },
    {
      "pmid": "28826498",
      "doi": "10.7554/eLife.27679",
      "source_type": "primary study report",
      "study_group": "PMID28826498",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Diffusion and AQP4-independent transport challenge uniform convection",
      "result_comparison": "The examined original report supports diffusion-based parenchymal movement and AQP4-independent transport in its preparation. It supplies an actual mechanistic contrast; differences in tracer delivery and compartments must be reconciled rather than dismissing one preparation.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/28826498/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\glymphatic-clearance\\examinations\\original-0-10-2400.json"
      ],
      "body_receipts": []
    }
  ],
  "grade_changed": false,
  "grade_change_note": "Source-based adjudication; no independent blinded regrade claimed.",
  "raw_receipts": [
    {
      "path": "deliverables\\hsef_v53_remaining_priority_11_15_2026-10-11\\glymphatic-clearance\\consensus-browser-2026-10-11.json",
      "sha256": "1f51e4e72fcb4b6af61d8d1ee6ffc1598b8ec3c75e65d02bdf8d0b84f9c3b0b1"
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  ],
  "independent_blinded_audit": false,
  "cutoff": "2026-10-09",
  "completed_utc": "2026-10-12T19:49:41.281918+00:00",
  "conclusion": "Endpoint hierarchy, experimental scope and original-source limits determine the evidence cards; provider wording does not override them."
}