Human associations, animal transfer experiments and clinical microbiome interventions address different causal steps. Recent adjunctive FMT findings strengthen an intervention line in depression, while human mediator specificity and generalization across psychiatric disorders remain unresolved.
This dated addendum adds selected evidence and tests that could resolve the remaining questions. It does not regrade the archived review.
Each question identifies a limit in the checked evidence. A missing search result alone does not establish a gap in the entire field.
Competing explanation: Taxa can be markers of diet, medication, inflammation or a broader microbial functional state.
Discriminating test: Replicated, strain/function-resolved randomized interventions with repeated metabolites, symptoms and prospective mediator analysis; stabilize medication and diet.
Competing explanation: Immune or circulating metabolite routes may contribute alongside vagal signals.
Discriminating test: Human autonomic and mediator measurements within controlled interventions, complemented by model blockade/rescue; do not equate autonomic correlation with necessity.
Competing explanation: Formulation, diagnosis, baseline microbiota, concurrent treatment or gastrointestinal improvement may modify effects.
Discriminating test: Independent multisite replication with prespecified diagnosis/strain strata, matching expectancy and gastrointestinal symptoms, and a clear primary psychiatric outcome.
Competing explanation: Short-lived symptom improvement may reflect concurrent antidepressant response or nonspecific treatment effects.
Discriminating test: Blinded longer follow-up with repeated microbial function and clinical relapse measures; record adherence, additional care and donor/product identity.
Electronic publication dates are used where recorded, with issue years shown separately. This is a selected chronology, not a claim of scientific priority or independent replication for every entry.
Depression-donor microbiota produced depressive-like behaviour and metabolic changes.
What it cannot establish: Germ-free host conditions and cross-species transfer bound applicability.
Depression-associated donor microbiota induced behavioural and physiological changes in recipients.
What it cannot establish: Rat phenotypes and donor confounding do not prove human disease sufficiency.
The tested formulation did not provide evidence of a symptom benefit.
What it cannot establish: A null formulation/population result does not exclude every microbiome intervention.
Depression scores and brain-activation measures improved with the tested strain.
What it cannot establish: IBS population and strain-specific intervention do not establish a general psychiatric mechanism.
Several taxa were associated with depressive symptoms across cohorts.
What it cannot establish: Association and inferred neuroactive potential do not establish effector delivery to the brain.
Vagotomy prevented the tested microbiota-induced behavioural and neurogenic effects.
What it cannot establish: Mouse route necessity is not established human vagal mediation.
Gut-health outcomes improved; a broad psychiatric benefit was not established.
What it cannot establish: Gastrointestinal or exploratory memory effects are not disorder-wide symptom efficacy.
The report linked improved adjunctive outcomes with engraftment, bile acids and mediation analysis.
What it cannot establish: Statistical mediation does not directly randomize the proposed bile-acid mechanism.
Case-specific Consensus records assisted gap discovery, chronology and targeted paper questions. Shared template wording about an amyloid-specific Deep follow-up is not evidence of a Deep run for this topic; the dated source records establish the actual use and access limits. Primary identifiers, selected abstract passages, correction notices and available primary-body passages were cross-checked. Generated absence cells, duplicate milestones and unsupported access claims were rejected.
Results Par32: vagotomy or sham surgery preceded transfer by two weeks; vagotomy prevented the tested behavioural/neurogenesis deficits in mice.
This focused addendum does not establish 50–70 complete primary Methods/Results examinations per review. Baseline reading receipts and scores retain their original scope.
Selected full-text checks: 1; abstract checks: 7; metadata-only anchors: 0. Complete-paper examinations credited in this update: 0.
New enrichment: HSEF v5.3 causal distinctions. Archived scorecard schema: 5.4; retained as recorded.
PMID 27491067 · DOI 10.1016/j.jpsychires.2016.07.019
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 27067014 · DOI 10.1038/mp.2016.44
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 28483500 · DOI 10.1053/j.gastro.2017.05.003
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 28068788 · DOI 10.1177/0004867416686694
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 36473852 · DOI 10.1038/s41467-022-34502-3
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 37131071 · DOI 10.1038/s41380-023-02071-6
Selected full-text passages checked. Results Par32: vagotomy or sham surgery preceded transfer by two weeks; vagotomy prevented the tested behavioural/neurogenesis deficits in mice.
PMID 39504580 · DOI 10.1093/schbul/sbae188
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
PMID 42309058 · DOI 10.1016/j.chom.2026.05.017
Selected abstract passages checked. Primary record and selected abstract passages checked; no complete-paper appraisal credited.
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