{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used complete abstracts/status records and selected original partial-body passages. No complete-paper audit or independent scientific peer review is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "The registered scope-matched gate is natural chronological primacy SC3, assessed Γ. Native old MuSC mediation supports a real scoped contribution and adult Dicer-2 supports lifespan intervention, but neither isolates gradual global mark erosion as the primary organismal clock. Calibrated H3K27me3 gain, mark redistribution and null longevity contrasts defeat the universal net-loss premise. Adult global triple-knockout evidence is a preprint outside the60 peer-reviewed count; the index empirical anchor cannot silently be upgraded.",
  "implications": "The registered scope-matched gate is natural chronological primacy SC3, assessed Γ. Native old MuSC mediation supports a real scoped contribution and adult Dicer-2 supports lifespan intervention, but neither isolates gradual global mark erosion as the primary organismal clock. Calibrated H3K27me3 gain, mark redistribution and null longevity contrasts defeat the universal net-loss premise. Adult global triple-knockout evidence is a preprint outside the60 peer-reviewed count; the index empirical anchor cannot silently be upgraded.",
  "limitations": "60 primary reports with 9 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}