{
  "slug": "histone-code",
  "canonical": "consensus_consistency_audit_2026-10-09/revised/histone-code/histone-code.review.md",
  "edition": "revised 2026-10-09; original edition had no adversarial approval",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "date": "2026-10-14",
  "level_before": "Γ",
  "level_after": "Γ",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "momentum_before": "Decisive work underway",
  "momentum_after": "Mechanistic only",
  "pmids_checked": 62,
  "pmids_failed": 0,
  "retractions_or_eoc": 0,
  "claims_spot_checked": 11,
  "findings": [
    {
      "id": "HC-1",
      "severity": "Major",
      "regression_introduced_by_revision": true,
      "location": "Consensus provenance reconciliation block; consensus-addendum.md",
      "issue": "The 9 October revision asserts 'The earlier adversarial approval refers to its original edition'. The original edition carries no adversarial banner or approval section.",
      "correction": "Sentence rescoped; the adversarial review of record is the one in this document."
    },
    {
      "id": "HC-2",
      "severity": "Major",
      "location": "AT A GLANCE table, M/S/D paragraph, scorecard extended_scoring_MSD.momentum",
      "issue": "Momentum 'Decisive work underway' supported only by completed publications; the artifact itself states no ongoing or pending result is asserted.",
      "correction": "Momentum set to 'Mechanistic only' and the artifact rewritten. Momentum modifies no letter, so no level or confidence change.",
      "lead_policy": "Decisive work underway requires work actually being run; a completed publication never satisfies it."
    },
    {
      "id": "HC-3",
      "severity": "Major",
      "location": "scorecard final_score.confidence_rationale",
      "issue": "Confidence band justified partly by reading access.",
      "correction": "Rationale rewritten to rest on evidence density and reproducibility; band re-derived under the lead's two-step test and retained at Moderate.",
      "lead_policy": "Access depth struck as a determinant; band re-derived from remaining evidence-quality concerns."
    },
    {
      "id": "HC-4",
      "severity": "Minor",
      "location": "Review prose, M/S/D paragraph, evidence card [5]; mirrored in the scorecard",
      "issue": "Glued author-year and word tokens: Zhang2020, Harris2023, Policarpi2024, Wang2023, Local2018, steps3/4, readerdomain.",
      "correction": "Spaces and hyphen restored."
    }
  ],
  "rejected_findings": [
    "Scope-matched aggregation applied correctly: SC3 is the scope-matched subclaim and sets the Γ headline; the Ζ subclaim SC2 is narrower (individual marks) and reported separately.",
    "'Best-supported rival' correctly rendered: models_evaluated[0] is M2 (rank 1, is_nominal false); the nominal model sits at rank 3.",
    "PMID 38724747 described as an endogenous MLL2 catalytic knock-in with mark restoration: confirmed in the paper's own body (Mll2/Kmt2b Y2602A knock-in ESCs; 3,102 promoter peaks lost, 15,244 retained). Challenged and rejected.",
    "'NURF writer deletions/truncations' is accurate against the source (Gcn5/Jil1 writer deletions; BPTF/NURF301 reader-domain truncations) and is spelled out in the interpretation section.",
    "KAT6B (39731917), H4 factorial (15795371), TRIM33 (22196728), BPTF (21596426) and 36859550 attributions match their abstracts.",
    "Compact in-text PMID lists are consistent house style; left unchanged.",
    "Validator warning v5.claim_form 'phenomenon': rejected per convention.",
    "Print vs e-pub year differences of ±1 at five refs: acceptable per convention.",
    "No dropped collective authors, no empty DOI fields, no 'PMIDnot supplied' strings."
  ],
  "propagation_strings": [
    {
      "old": "The earlier adversarial approval refers to its original edition; this provenance supplement is not a new independent or blinded adjudication. No score or confidence change is made by this reconciliation.",
      "new": "This provenance supplement is not a new independent or blinded adjudication. The original edition of this review carried no adversarial approval; the adversarial review of record is the one recorded in ADVERSARIAL REVIEW AND APPROVAL below. No score or confidence change is made by this reconciliation.",
      "also_in": [
        "consensus-addendum.md"
      ]
    },
    {
      "old": "| Decisive work underway | Stable | Contested |",
      "new": "| Mechanistic only | Stable | Contested |"
    },
    {
      "old": "Momentum: Decisive work underway.",
      "new": "Momentum: Mechanistic only."
    }
  ],
  "divergent_copies_untouched": [
    "hsef_v53_popularity_ranks_36_40_2026-10-08/histone-code/histone-code.review.md"
  ],
  "validator": "PASS (0 fail, 1 warn, 31 pass); the warning is the standing-reject v5.claim_form 'phenomenon' notice",
  "collective_author_scan": "Both variants checked (leading-comma drop and consortium-name truncation to Group/Network/Consortium/etc.); 62/62 first authors are genuine personal names matching the PubMed record. None found."
}