{
  "completed": true,
  "status": "completed_original_source_reconciliation",
  "provider_mode": "Consensus Pro signed-in browser; observed response and citation-link mappings",
  "queries": [
    "https://consensus.app/search/hiv-infection-causality-aids/2tn6gPRISjWM32PHrceoXw/"
  ],
  "query_record_note": "Observed thread URL and visible request/response in raw receipt; no unobserved query payload reconstructed.",
  "primary_comparison_count": 5,
  "primary_comparisons": [
    {
      "pmid": "26192873",
      "doi": "10.1056/NEJMoa1506816",
      "source_type": "primary study report",
      "study_group": "NCT00867048",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Earlier suppression reduces clinical progression.",
      "result_comparison": "Original START abstract shows a positive primary clinical composite for immediate ART, supporting disease modification rather than merely changing a laboratory marker.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/26192873/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\hiv-aids\\examinations\\results-48-63.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\hiv-aids\\body-presentation-receipts\\26192873-s0-p4-5-8.json",
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\hiv-aids\\body-presentation-receipts\\26192873-s1-p4-5-6-8.json"
      ]
    },
    {
      "pmid": "17135583",
      "doi": "10.1056/NEJMoa062360",
      "source_type": "primary study report",
      "study_group": "SMART",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Withdrawal of suppression tests progression.",
      "result_comparison": "Original SMART abstract links episodic treatment with increased opportunistic disease/death and rising viral RNA. This controlled perturbation carries stronger causal weight than correlation alone.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/17135583/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\hiv-aids\\examinations\\results-48-63.json"
      ],
      "body_receipts": []
    },
    {
      "pmid": "24602844",
      "doi": "10.1016/S1473-3099(13)70692-3",
      "source_type": "primary study report",
      "study_group": "HPTN052",
      "access_depth": "full_text_partial",
      "consensus_aspect": "HPTN 052 supports earlier treatment.",
      "result_comparison": "Original clinical follow-up abstract retains the nonsignificant primary composite (p=.074) while noting the positive AIDS-event comparison (p=.031). Secondary benefit is not substituted for a primary result.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/24602844/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\hiv-aids\\examinations\\results-48-63.json"
      ],
      "body_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\hiv-aids\\body-presentation-receipts\\24602844-s2-p1-2-4.json"
      ]
    },
    {
      "pmid": "26423816",
      "doi": "10.1016/S2352-3018(14)70016-5",
      "source_type": "primary study report",
      "study_group": "CASCADE_POOLED",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Untreated progression-free fractions decline with time.",
      "result_comparison": "Original CASCADE abstract defines progression-free jointly as no AIDS, ART-naive and CD4 at least 500. Those percentages are not simply the percentage remaining AIDS-free.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/26423816/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\hiv-aids\\examinations\\results-48-63.json"
      ],
      "body_receipts": []
    },
    {
      "pmid": "18456875",
      "doi": "10.1182/blood-2007-12-127878",
      "source_type": "primary study report",
      "study_group": "PMID18456875",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "HIV infection is not required for every low-CD4 syndrome.",
      "result_comparison": "Original ICL follow-up shows an HIV-negative immune phenotype. The registered causal claim concerns HIV-associated AIDS, not every immune-deficiency presentation.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/18456875/",
      "source_examination_receipts": [
        "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\hiv-aids\\examinations\\results-32-48.json"
      ],
      "body_receipts": []
    }
  ],
  "grade_changed": false,
  "grade_change_note": "Comparison does not introduce an independently blinded regrade; bounded case adjudication remains source-based.",
  "raw_receipts": [
    {
      "path": "deliverables\\hsef_v53_remaining_priority_06_10_2026-10-09\\hiv-aids\\consensus-browser-2026-10-11.json",
      "sha256": "d6c67ad2cdc716058b9ec826180777f138241ba7a064973bdc7129cd4dc0cded"
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  "independent_blinded_audit": false,
  "cutoff": "2026-10-09",
  "completed_utc": "2026-10-12T02:11:33.325431+00:00",
  "conclusion": "Specific qualifiers and endpoint hierarchy above are retained in the evidence cards; AI wording does not override the original sources."
}