{
  "slug": "infection-triggered-autoimmunity",
  "round": 2,
  "date": "2026-10-14",
  "authoring_model": "Sol 6.1",
  "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
  "canonical": "consensus_consistency_audit_2026-10-09\\revised\\infection-triggered-autoimmunity\\infection-triggered-autoimmunity.review.md",
  "level_before": "Β",
  "level_after": "Β",
  "confidence_before": "Moderate",
  "confidence_after": "Moderate",
  "confidence_band_rederived": true,
  "approval": "Approved as revised",
  "pmids_checked": 70,
  "pmids_failed": 0,
  "retractions_found": 0,
  "errata_verified": ["33055421", "30455315", "29724927"],
  "claims_spot_checked": 12,
  "validator": {"tool": "validate_review.py", "version": "2.3", "ok": true, "FAIL": 0, "WARN": 1, "PASS": 31},
  "counts": {"critical": 0, "major": 2, "minor": 1, "editorial": 0},
  "findings": [
    {
      "id": "IA-1",
      "severity": "Major",
      "category": "false provenance / spliced sentence",
      "location": "Consensus provenance reconciliation block",
      "original": "The earlier adversarial approval refers to its original edition; this provenance supplement is not a new independent or blinded adjudication.",
      "corrected": "No earlier adversarial approval exists for any edition of this review; this provenance supplement is not an independent or blinded adjudication.",
      "evidence": "No edition carries an ADVERSARIAL REVIEW AND APPROVAL section or approval line; the 2026-10-06 pass covered 30 other slugs."
    },
    {
      "id": "IA-2",
      "severity": "Minor",
      "category": "rendering defect (empty DOI field)",
      "location": "REFERENCES entry 41 (Sakaguchi 1995)",
      "original": "DOI: .",
      "corrected": "DOI: none assigned (pre-DOI Journal of Immunology record).",
      "evidence": "PubMed holds no DOI for PMID 7636184."
    },
    {
      "id": "IA-3",
      "severity": "Major",
      "category": "confidence band justified by reviewer access depth",
      "location": "AT A GLANCE (new Confidence basis paragraph); final_score.confidence_rationale and two mirrored copies",
      "original": "70 primary reports with 6 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness.",
      "corrected": "Rationale grounded in evidence density and reproducibility, with reviewer access depth explicitly excluded as a determinant.",
      "evidence": "Lead policy; hsef-framework.md section Confidence band. Two-step test applied; substantive evidence-quality concerns remain, so Moderate stands."
    }
  ],
  "rejected_findings": [
    "Overall Β from weakest-link including a descriptive antecedence subclaim - argued and upheld; rule pre-registered, both alternatives (Ε/Ε) published in four places, SKILL.md Step 3 forbids post-hoc rule-shopping.",
    "AT A GLANCE headline reading stronger than Β - reports the matrix contents with the aggregation basis stated adjacently.",
    "Best-supported rival renderer defect - rank 1 is is_nominal false; nominal M1 ranks 3.",
    "Six print vs e-pub year differences of one (Kim, Kamitani, Traka, McCall, Lindfors, Zegarra-Ruiz) - standing convention.",
    "Three title mismatches from PubMed field loss (CD4+/CD8+ superscripts; dropped italicised species name) - standing convention.",
    "v5.claim_form 'phenomenon' warning - standing convention.",
    "REVIEWER NOTES vs spliced Consensus section - no contradiction.",
    "Momentum already 'Mechanistic only'; named artifacts are completed work.",
    "Collective authors - none in this reference list."
  ],
  "residual_limitations": "Access depth unchanged (6 partial-body, 64 abstract/status). Three linked errata unexamined in substance. Partial-body detail for Godschalk, Lanz, Wen, Krogvold and Younis not re-verifiable from abstracts; not contradicted. Cohort and isolate-platform overlap only partly audited.",
  "changed_files": [
    {"path": "infection-triggered-autoimmunity.review.md", "sha256": "8590f4e2b7d5349e09eb457b26c4267eff1b23d122d82ce0227b44611ec18be3", "bytes": 120721},
    {"path": "infection-triggered-autoimmunity.scorecard.json", "sha256": "686349b36af9ff83321daefce68cb3182fe107d9b13948373866cc16927da4c1", "bytes": 352350},
    {"path": "SHA256.txt", "note": "regenerated"},
    {"path": "validation-report.json", "note": "re-run, ok=true"}
  ],
  "propagate_to": [],
  "divergent_copies_not_touched": [
    "hsef_v53_popularity_ranks_26_30_2026-10-07\\infection-triggered-autoimmunity\\infection-triggered-autoimmunity.review.md"
  ],
  "consensus_questions": [
    "Has any human study measured immune-tolerance function (Treg number/function or checkpoint signalling) in prediagnostic samples BEFORE autoimmune onset, rather than inferring a baseline tolerance deficit from post-onset inflammation?"
  ]
}