# Consensus and original-source cross-check: Inflammatory Depression Hypothesis

Literature cutoff: 9 October 2026. Reconciliation completed 11 October 2026. Consensus Pro browser output is a discovery/synthesis aid; original source sections determine attribution. Provider meters are not evidence probabilities or examined-primary counts.

## High CRP may identify benefit from anti-TNF treatment.
Original infliximab Methods/Results show an overall null primary outcome and an exploratory CRP threshold identified from the results. A focused responder comparison is nonsignificant; this is not a confirmed prospective subtype. [Original primary source: PMID 22945416](https://pubmed.ncbi.nlm.nih.gov/22945416/). DOI: 10.1001/2013.jamapsychiatry.4. Access: full_text_partial.

## High-inflammation patients may respond to minocycline.
Original MINDEP body uses CRP at least 1 for entry and an overall null. The higher-CRP finding is exploratory and includes only six participants assigned minocycline. [Original primary source: PMID 33504955](https://pubmed.ncbi.nlm.nih.gov/33504955/). DOI: 10.1038/s41386-020-00948-6. Access: full_text_partial.

## Prospective biomarker stratification could validate the subgroup.
Original PREDDICT abstract reports prespecified CRP stratification without a positive treatment-by-stratum result. The later follow-up is the same parent trial and does not supply independent replication. [Original primary source: PMID 37635396](https://pubmed.ncbi.nlm.nih.gov/37635396/). DOI: 10.1111/jnc.15946. Access: abstract_metadata.

## Inflammatory challenge can change depressive symptoms.
Original challenge body defines an acute anhedonia endpoint over hours, retains a nonsignificant overall three-way interaction and reports later improvement on MADRS. It does not demonstrate sustained new MDD. [Original primary source: PMID 40264292](https://pubmed.ncbi.nlm.nih.gov/40264292/). DOI: 10.1176/appi.ajp.20240142. Access: full_text_partial.

## Older adults can be susceptible to inflammatory mood effects.
Original body excludes recent MDD and measures short-lived mood ratings. This cannot establish sustained biomarker-defined major depression. [Original primary source: PMID 40668551](https://pubmed.ncbi.nlm.nih.gov/40668551/). DOI: 10.1001/jamapsychiatry.2025.1327. Access: full_text_partial.

## Methods wording
Consensus was used to identify literature and cross-check specific claims about study design, endpoints, scope and research gaps. Those claims were checked against original primary abstracts/status records and, for selected studies, original Methods or Results passages. Consensus output was not treated as original full text. Source-specific access depth and receipts are retained. Scite supplied one five-anchor citation-context/tally query; returned contexts were outgoing references, not an audited incoming contradiction set. SciSpace supplied one discovery pass; it added no primary-count credit.