{
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  "status": "completed_original_source_reconciliation",
  "provider_mode": "Consensus Pro signed-in browser; observed response and citation-link mappings",
  "queries": [
    "https://consensus.app/search/peripheral-inflammation-and-depression/HEr9yXljQ3qYmROV-QbJuQ/"
  ],
  "query_record_note": "Observed thread URL and visible request/response in raw receipt; no unobserved query payload reconstructed.",
  "primary_comparison_count": 5,
  "primary_comparisons": [
    {
      "pmid": "22945416",
      "doi": "10.1001/2013.jamapsychiatry.4",
      "source_type": "primary study report",
      "study_group": "NCT00463580",
      "access_depth": "full_text_partial",
      "consensus_aspect": "High CRP may identify benefit from anti-TNF treatment.",
      "result_comparison": "Original infliximab Methods/Results show an overall null primary outcome and an exploratory CRP threshold identified from the results. A focused responder comparison is nonsignificant; this is not a confirmed prospective subtype.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/22945416/",
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      "doi": "10.1038/s41386-020-00948-6",
      "source_type": "primary study report",
      "study_group": "MINDEP",
      "access_depth": "full_text_partial",
      "consensus_aspect": "High-inflammation patients may respond to minocycline.",
      "result_comparison": "Original MINDEP body uses CRP at least 1 for entry and an overall null. The higher-CRP finding is exploratory and includes only six participants assigned minocycline.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/33504955/",
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    {
      "pmid": "37635396",
      "doi": "10.1111/jnc.15946",
      "source_type": "primary study report",
      "study_group": "PREDDICT",
      "access_depth": "abstract_metadata",
      "consensus_aspect": "Prospective biomarker stratification could validate the subgroup.",
      "result_comparison": "Original PREDDICT abstract reports prespecified CRP stratification without a positive treatment-by-stratum result. The later follow-up is the same parent trial and does not supply independent replication.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/37635396/",
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    {
      "pmid": "40264292",
      "doi": "10.1176/appi.ajp.20240142",
      "source_type": "primary study report",
      "study_group": "PMID40264292",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Inflammatory challenge can change depressive symptoms.",
      "result_comparison": "Original challenge body defines an acute anhedonia endpoint over hours, retains a nonsignificant overall three-way interaction and reports later improvement on MADRS. It does not demonstrate sustained new MDD.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/40264292/",
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    {
      "pmid": "40668551",
      "doi": "10.1001/jamapsychiatry.2025.1327",
      "source_type": "primary study report",
      "study_group": "PMID40668551",
      "access_depth": "full_text_partial",
      "consensus_aspect": "Older adults can be susceptible to inflammatory mood effects.",
      "result_comparison": "Original body excludes recent MDD and measures short-lived mood ratings. This cannot establish sustained biomarker-defined major depression.",
      "original_source": "https://pubmed.ncbi.nlm.nih.gov/40668551/",
      "source_examination_receipts": [
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  "grade_changed": false,
  "grade_change_note": "Comparison does not introduce an independently blinded regrade; bounded case adjudication remains source-based.",
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  "independent_blinded_audit": false,
  "cutoff": "2026-10-09",
  "completed_utc": "2026-10-12T02:11:33.676946+00:00",
  "conclusion": "Specific qualifiers and endpoint hierarchy above are retained in the evidence cards; AI wording does not override the original sources."
}