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    "rationale": "Epigenetic states are causally manipulable and functional reversal is demonstrated in constrained mouse tissues, most convincingly aged retina. The evidence does not isolate progressive information loss from damage responses or establish restoration of a defined youthful state as the mediator, primary rate-limiting cause, or broadly replicated healthspan intervention."
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    "reconciliation_existing": "Yes; 9 primary identifiers and abstract/metadata checks documented; service-reported additional full-text details kept distinct.",
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