{
  "title": "What this review means",
  "includeSubclaimIllustrations": false,
  "redteamReviewed": true,
  "accessNotice": "Source checking used bounded original primary abstract passages/status records and selected original partial-body passages. No complete-abstract or complete-paper audit, or independent scientific peer review, is claimed. Detailed access counts and limitations appear in the review.",
  "overview": "Saturated-for-cis-unsaturated replacement can raise LDL/apoB and is expected to raise ASCVD risk; the net clinical effect depends on the replacement, food matrix and exposure context.",
  "implications": "Overall Ε follows preregistered SC3. The isolated biomarker component is Γ and the independently convergent particle-to-ASCVD component is Η. SC3 is assessed on their assembled complementary evidence with clinical dietary results, not by reimposing the biomarker cap on the whole set. Comparator-specific effects, historical endpoint conflicts, food matrix and uncertain selective mediation prevent broad diet-specific Ζ. This remains a bounded reviewer judgement, not a numerical estimate of individual risk.",
  "limitations": "53 primary reports with 4 selected partial-body examinations; density, heterogeneous controls and incomplete access set the confidence, not correctness. The grade applies to the exact registered claim; stronger findings for narrower subclaims remain separate. No complete-paper audit or blinded calibration is claimed. This educational review does not establish an individual treatment recommendation."
}