{
  "cutoff": "2026-10-09",
  "note": "Selected publication milestones, not an exhaustive history or priority-of-discovery determination.",
  "milestones": [
    {
      "year": "1979",
      "pmid": "393644",
      "doi": "10.1093/ije/8.2.99",
      "title": "Dietary prevention of coronary heart disease: the Finnish Mental Hospital Study.",
      "interpretation": "Finnish hospital dietary periods test cholesterol and coronary outcomes in a limited historical design.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/393644/"
    },
    {
      "year": "1989",
      "pmid": "2643423",
      "doi": "10.1161/01.atv.9.1.129",
      "title": "Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey.",
      "interpretation": "Original Minnesota trial clinical report; one parent study with the later reanalysis.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/2643423/"
    },
    {
      "year": "2013",
      "pmid": "23386268",
      "doi": "10.1136/bmj.e8707",
      "title": "Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis.",
      "interpretation": "Recovered Sydney trial data sharpen uncertainty about intervention composition and mortality.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/23386268/"
    },
    {
      "year": "2016",
      "pmid": "27071971",
      "doi": "10.1136/bmj.i1246",
      "title": "Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73).",
      "interpretation": "Recovered Minnesota data distinguish lipid response from observed mortality.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/27071971/"
    },
    {
      "year": "2017",
      "pmid": "28304224",
      "doi": "10.1056/NEJMoa1615664",
      "title": "Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease.",
      "interpretation": "FOURIER tests pharmacological LDL lowering with clinical event endpoints.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/28304224/"
    },
    {
      "year": "2020",
      "pmid": "32203549",
      "doi": "10.1371/journal.pmed.1003062",
      "title": "Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.",
      "interpretation": "Multivariable genetics prioritizes apoB across correlated lipid measures.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/32203549/"
    },
    {
      "year": "2024",
      "pmid": "39111551",
      "doi": "10.1016/j.ajcnut.2024.07.032",
      "title": "Variation of LDL cholesterol in response to the replacement of saturated with unsaturated fatty acids: a nonrandomized, sequential dietary intervention; the Reading, Imperial, Surrey, Saturated fat Cholesterol Intervention (\"RISSCI\"-1) study.",
      "interpretation": "RISSCI-1 documents heterogeneous responses in a sequential design.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/39111551/"
    },
    {
      "year": "2026",
      "pmid": "42664559",
      "doi": "10.1016/j.atherosclerosis.2026.121884",
      "title": "Impact of saturated fat absorption on serum low density lipoprotein-cholesterol response to the replacement of saturated with unsaturated fats in healthy males. The 'Reading, Imperial, Surrey, Saturated fat Cholesterol Intervention-2 (RISSCI-2)' non-randomised sequential dietary intervention study.",
      "interpretation": "Response-selected RISSCI-2 examines a proposed absorption explanation.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/42664559/"
    }
  ],
  "gaps": [
    "Selective diet-specific clinical mediation remains weaker than particle causality.",
    "Cis-MUFA and cis-PUFA, individual SFA species and food matrices need separate effect estimates.",
    "Historical trans-fat exposure and incomplete data recovery remain unresolved; contamination must not be asserted as an established explanation of nulls.",
    "Mean response and responder-defined follow-up are distinct populations.",
    "More diverse clinical populations and complete correction/supplement checks are needed."
  ],
  "decisive_experiment": "Independently run, preregistered long-term isoenergetic replacement trial with fixed SFA species, cis-PUFA/cis-MUFA comparators, matched food matrices, trans-fat measurement, sustained apoB separation and blinded adjudicated ASCVD outcomes; prospectively test mediation and competing metabolic pathways."
}