{
 "slug": "long-covid-viral-persistence",
 "round": 2,
 "date": "2026-10-14",
 "authoring_model": "Sol 6.1",
 "adversarial_reviewer": "Claude Opus 5.5 (Anthropic)",
 "canonical_path": "consensus_consistency_audit_2026-10-09/revised/long-covid-viral-persistence/long-covid-viral-persistence.review.md",
 "level_before": "Γ",
 "level_after": "Γ",
 "confidence_before": "Moderate",
 "confidence_after": "Moderate",
 "role_before": "epiphenomenon",
 "role_after": "epiphenomenon",
 "counts": {
  "critical": 0,
  "major": 0,
  "minor": 3,
  "editorial": 0,
  "distinct_string_corrections": 3,
  "occurrences_replaced": 3
 },
 "pmids_checked": 56,
 "pmids_failed": 0,
 "retraction_flags": 0,
 "claims_spot_checked": 10,
 "collective_author_bug_present": false,
 "empty_doi_fields": 0,
 "erratum_string_defects": 0,
 "validator": {
  "stored_report_v2_3_ok": true,
  "rerun_with_bundled_v5_4": "1 FAIL (v5.lay_summary, v5.4-only), 1 WARN (v5.claim_form disjunction, rejected by convention), 32 pass",
  "output": "validator.txt"
 },
 "findings": [
  {
   "id": 1,
   "severity": "Minor",
   "class": "internal-consistency/regression",
   "location": "REVIEWER NOTES",
   "old": "No independent blind grading, Consensus, Scite or independent scientific peer review was performed.",
   "new": "No independent blind grading, Consensus, Scite or independent scientific peer review was performed for the original review; the dated 9 October 2026 Consensus consistency validation above is a later provenance supplement and is not an independent blinded adjudication.",
   "evidence": "The 2026-10-09 revision inserted a Consensus consistency validation section while the preserved REVIEWER NOTES still denied any Consensus work. Same defect as the metformin review in this group.",
   "is_regression": true
  },
  {
   "id": 2,
   "severity": "Minor",
   "class": "rendering",
   "location": "Momentum line",
   "old": "(PMIDs38848477,40188838,42673984)",
   "new": "(PMIDs 38848477, 40188838, 42673984)"
  },
  {
   "id": 3,
   "severity": "Minor",
   "class": "rendering",
   "location": "Momentum line",
   "old": "(PMIDs41794369,41963730)",
   "new": "(PMIDs 41794369, 41963730)"
  }
 ],
 "revision_block_verification": {
  "result": "accurate; no substantive regression",
  "checked": [
   "Zuo PMID 38663423: 225 patients, residual clinical specimens, 4-month telephone questionnaire, OR 5.17 (95% CI 2.64-10.13); authors call for work to verify a mechanistic link",
   "STOP-PASC PMID 38848477: 155 participants, 15-week blinded placebo-controlled, pooled six-symptom primary at week 10, null; 153/155 vaccinated",
   "PAX LC PMID 40188838: phase 2, 100 enrolled, day-28 PROMIS-29 PHSS adjusted mean difference -0.55 (95% CI -2.32 to 1.21, p=0.54), NCT05668091",
   "RECOVER-VITAL PMID 42673984: 959 mITT across cognitive/autonomic/exercise phenotypes, no significant primary benefit under 15- or 25-day regimens, NCT05595369"
  ]
 },
 "rejected_findings": [
  "Aggregation primary-subclaim with SC3 named; alternatives weakest-link Β and scope-matched Γ both correct.",
  "Causal role 'epiphenomenon' correctly derived at step 2.",
  "Momentum 'Mechanistic only' carries its artifact.",
  "Causal tally 7 matches the 7 printed inventory items and the score card.",
  "v5.claim_form disjunction warning: 'antigen or RNA' are two measurements of one parent reservoir claim, decomposed in the subclaim matrix.",
  "v5.lay_summary FAIL is a v5.4-only check on a v5.3 review.",
  "review_metadata.reviewer = 'Codex' is identical across every score card in the corpus - house provenance, flagged not changed."
 ],
 "residual_limitations": [
  "Only 3 of 56 reports examined at partial-body depth.",
  "Could not re-derive: RECOVER-VITAL's 'no secondary endpoint differences' (the abstract names but does not report all secondary measures), and the claim that the archived raw Consensus file misassigns a PMID to the STOP-PASC DOI."
 ],
 "divergent_copies_left_untouched": [
  "hsef_v53_remaining_priority_01_05_2026-10-09/long-covid-viral-persistence/long-covid-viral-persistence.review.md"
 ],
 "propagate_to": [],
 "consensus_question": "In people with established long COVID, does an intervention that demonstrably reduces tissue SARS-CoV-2 RNA or antigen produce a corresponding reduction in symptom burden?",
 "sha256_review_md_after": "f0e861fb75eed81cd41c7e2dcc29a777c817c3a579b71c3ef82b38f44f4416d9",
 "bytes_review_md_after": 85030
}